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Volume 79
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Article

Detection, Isolation and Characterization of Principal Synthetic Route Indicative Impurities in Verapamil Hydrochloride

by
Viswanathan SRINIVASAN
1,2,*,
Hariharan SIVARAMAKRISHNAN
3 and
Balakrishnan KARTHIKEYAN
2
1
Analytical Development Laboratory, Piramal Healthcare Ltd, Ennore, Chennai 600 057, India
2
Department of Chemistry, Annamalai University, Annamalainagar 608 002, India
3
Research and Development Laboratory, Piramal Healthcare Ltd, Ennore, Chennai 600 057, India
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2011, 79(3), 555-568; https://doi.org/10.3797/scipharm.1101-19
Submission received: 26 January 2011 / Accepted: 8 May 2011 / Published: 8 May 2011
Versions Notes

Abstract

Two unknown impurities were detected in verapamil hydrochloride bulk drug using isocratic reversed-phase high performance liquid chromatography (HPLC). These impurities were isolated by preparative HPLC. Spectral data for the isolated impurities were collected. Based on the spectral data derived from two-dimensional nuclear magnetic resonance (2D-NMR) spectroscopy and mass spectrometry (MS), impurity-1 and impurity-2 were characterized as 2-(3,4-dimethoxyphenyl)-3-methylbut-2-enenitrile and 2-(3,4-dimethoxyphenyl)-2-isopropyl-3-methylbutanenitrile, respectively.
Keywords: Verapamil hydrochloride; NMR; HPLC; MS; Impurity Analysis Verapamil hydrochloride; NMR; HPLC; MS; Impurity Analysis

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MDPI and ACS Style

SRINIVASAN, V.; SIVARAMAKRISHNAN, H.; KARTHIKEYAN, B. Detection, Isolation and Characterization of Principal Synthetic Route Indicative Impurities in Verapamil Hydrochloride. Sci. Pharm. 2011, 79, 555-568. https://doi.org/10.3797/scipharm.1101-19

AMA Style

SRINIVASAN V, SIVARAMAKRISHNAN H, KARTHIKEYAN B. Detection, Isolation and Characterization of Principal Synthetic Route Indicative Impurities in Verapamil Hydrochloride. Scientia Pharmaceutica. 2011; 79(3):555-568. https://doi.org/10.3797/scipharm.1101-19

Chicago/Turabian Style

SRINIVASAN, Viswanathan, Hariharan SIVARAMAKRISHNAN, and Balakrishnan KARTHIKEYAN. 2011. "Detection, Isolation and Characterization of Principal Synthetic Route Indicative Impurities in Verapamil Hydrochloride" Scientia Pharmaceutica 79, no. 3: 555-568. https://doi.org/10.3797/scipharm.1101-19

APA Style

SRINIVASAN, V., SIVARAMAKRISHNAN, H., & KARTHIKEYAN, B. (2011). Detection, Isolation and Characterization of Principal Synthetic Route Indicative Impurities in Verapamil Hydrochloride. Scientia Pharmaceutica, 79(3), 555-568. https://doi.org/10.3797/scipharm.1101-19

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