Protamine Based siRNA-Nanoparticles: Particle Composition Dependant Influences on RNA Interference Efficiency

D. REISCHL; E. JANTSCHER-KRENN; E. BERNHART; W. SATTLER; A. ZIMMER

doi:10.3797/scipharm.cespt.8.PNM16

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12 July 2010

Protamine Based siRNA-Nanoparticles: Particle Composition Dependant Influences on RNA Interference Efficiency

and

Institute of Pharmaceutical Sciences, Department of Pharmaceutical Technology, Karl-Franzens-University Graz, Austria

Institute of Molecular Biology and Biochemistry, Medical University Graz, Austria

Author to whom correspondence should be addressed.

Sci. Pharm.2010, 78(3), 686;https://doi.org/10.3797/scipharm.cespt.8.PNM16

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Abstract

The major limitations for the use of small interfering RNA (siRNA) in vivo and in vitro are the relatively high molecular weight, the negative charge, and the susceptibility to nuclease degradation [1]. [...]

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