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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Sci. Pharm. 2009, 77(Posters (PO)), 236; (registering DOI)

Microspheres Containing Carnosic Acid for the Treatment of Basil Fungal Diseases

Dipartimento di Chimica e Tecnologie Farmaceutiche e Alimentari, Università di Genova, Via Brigata Salerno 13, 16147 Genova, Italy
Centro Regionale di Sperimentazione e Assistenza Agricola, Camera di Commercio I.A.A. di Savona, Regione Rollo, 98, 17031 Albenga, Italy
Author to whom correspondence should be addressed.
Received: 16 April 2009 / Accepted: 16 April 2009 / Published: 16 April 2009
PDF [210 KB, uploaded 12 May 2017]


Microspheres loaded with carnosic acid (CA) as an active ingredient which was extracted from various species of Salvia L., were prepared by a spray drying technology. The matrix of the microspheres consisted of 85% deacetylated chitosan (average MW 55000 kDa), poloxamer P407 and carnosic acid. Briefly, chitosan and poloxamer P407 were dissolved in 1% v/v acetic acid followed by dispersion of carnosic acid under vigorous stirring. The dispersion was then fed into a spray dryer (190 Mini, Büchi, Flawil, Switzerland) and processed under the following operative conditions: T inlet 180°C, T outlet 120°C, air aspiration 70% and peristaltic pump 15% (feeding rate 4 mL/min). This process yielded microspheres with 5-8 μm in diameter containing 17% active ingredients corresponding to an encapsulation efficiency of 45% and a practical yield of 34%.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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RUSSO, E.; BISIO, A.; ROMUSSI, G.; PARODI, B.; CAVIGLIOLI, G.; MINUTO, G.; CAFAGGI, S. Microspheres Containing Carnosic Acid for the Treatment of Basil Fungal Diseases. Sci. Pharm. 2009, 77, 236.

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