Functionability of NMDA-Receptors in an in vitro model of the Blood-Brain-Barrier

M. FREIDL; W. NEUHAUS; M. WIRTH; F. GABOR; C. R. NOE

doi:10.3797/scipharm.oephg.21.PO-19

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Abstract

16 April 2009

Functionability of NMDA-Receptors in an in vitro model of the Blood-Brain-Barrier

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Department of Medicinal Chemistry, University of Vienna, Althanstraße 14, 1090 Vienna, Austria

PharmaCon GmbH, Riglergasse 4/5, 1180 Vienna, Austria

Department of Pharmaceutical Technology and Biopharmaceutics, University of Vienna, Althanstraße 14, 1090 Vienna, Austria

Author to whom correspondence should be addressed.

Sci. Pharm.2009, 77(7), 218;https://doi.org/10.3797/scipharm.oephg.21.PO-19

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Abstract

A diversity of disease processes and conditions such as Alzheimer´s disease, schizophrenia, epilepsy and stroke – although they are caused by different mechanism – share one common target: the NMDA-receptor [1]. Recent studies reported the presence and the participation of this glutamate-gated ion-channel in major regulatory mechanisms at the blood-brain barrier (BBB). In order to show the functionability of this receptor and his effects on the BBB, we used an in vitro model based on human cell line ECV304 [2].

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