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Gadolinium-labeled PLGA Nanoparticles for Magnetic Resonance Imaging
Department of Pharmaceutical Technology and Biopharmaceutics, University of Vienna, Althanstraße 14, A-1090, Vienna, Austria
Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, PO Box 513, 5600 MB, Eindhoven, The Netherlands
Department of Environmental Geosciences, University of Vienna, Althanstraße 14, A-1090, Vienna, Austria
Author to whom correspondence should be addressed.
Received: 16 April 2009 / Accepted: 16 April 2009 / Published: 16 April 2009
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Abstract To date, the main two classes of clinically used contrast agents for magnetic resonance imaging (MRI) are soluble paramagnetic gadolinium chelates and superparamagnetic iron oxide particles. While iron oxides predominantly increase T2-relaxivity and thus provide negative contrast, gadolinium chelates are often requested as they increase T1-relaxivity and enhance positive contrast. As particulate contrast agents are preferable due to a more favorable signal-to-noise ratio, the goal of our present work was the development of poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles labeled with chelated gadolinium.
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RATZINGER, G.; AGRAWAL, P.; WIRTH, M.; KÖRNER, W.; NICOLAY, K.; GABOR, F. Gadolinium-labeled PLGA Nanoparticles for Magnetic Resonance Imaging. Sci. Pharm. 2009, 77, 191.
RATZINGER G, AGRAWAL P, WIRTH M, KÖRNER W, NICOLAY K, GABOR F. Gadolinium-labeled PLGA Nanoparticles for Magnetic Resonance Imaging. Scientia Pharmaceutica. 2009; 77(Short Lectures (SL)):191.
RATZINGER, G.; AGRAWAL, P.; WIRTH, M.; KÖRNER, W.; NICOLAY, K.; GABOR, F. 2009. "Gadolinium-labeled PLGA Nanoparticles for Magnetic Resonance Imaging." Sci. Pharm. 77, Short Lectures (SL): 191.
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