Next Article in Journal
Preparation and Biological Evaluation of a [55Co]-2-Acetylpyridine Thiosemicarbazone
Previous Article in Journal
Antiarrhythmic Activities of Some Newly Synthesized Tricyclic and Tetracyclic Thienopyridine Derivatives
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Sci. Pharm.
Volume 77
Issue 3
10.3797/scipharm.0901-30
scipharm-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

QSAR Study on 6-Substituted Benzimidazoles: An Insight into the Structural Requirement for the Angiotensin II AT1 Receptor Antagonist

by
Anurekha JAIN
1,* and
Subhash C. CHATURVEDI
2
1
Nahata College of Pharmacy, Rajiv Gandhi Technical University, Mhow-Neemuch Road 458001 Mandasur (M.P.), India
2
School of Pharmacy, Devi Ahilya VishawaVidalaya, Takshashila Parser Khandawa Road, 452003 Indore (M.P.), India
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2009, 77(3), 555-566; https://doi.org/10.3797/scipharm.0901-30
Submission received: 30 January 2009 / Accepted: 5 June 2009 / Published: 6 June 2009
Versions Notes

Abstract

With an aim to identify the structural requirements for selective AT1 angiotensin antagonistic activity, a quantitative structure activity relationship (QSAR) analysis was carried out on a series of 6-substituted benzimidazole derivatives. The QSAR expressions were generated using 28 compounds and the predictive ability of the resulting model was evaluated against a test set of 12 compounds. The internal (cross validated squared correlation coefficient) and external consistency (predictive correlation coefficient) of the QSAR model was 0.78 and 0.40 respectively. In the present work QSAR analysis reveals that geometrical, structural, and shape descriptors govern the angiotensin II AT1 antagonistic activity.
Keywords: Nonpeptide Angiotensin II Antagonist; AT1 receptor; QSAR; Hypertension; RAS Nonpeptide Angiotensin II Antagonist; AT1 receptor; QSAR; Hypertension; RAS

Share and Cite

MDPI and ACS Style

JAIN, A.; CHATURVEDI, S.C. QSAR Study on 6-Substituted Benzimidazoles: An Insight into the Structural Requirement for the Angiotensin II AT1 Receptor Antagonist. Sci. Pharm. 2009, 77, 555-566. https://doi.org/10.3797/scipharm.0901-30

AMA Style

JAIN A, CHATURVEDI SC. QSAR Study on 6-Substituted Benzimidazoles: An Insight into the Structural Requirement for the Angiotensin II AT1 Receptor Antagonist. Scientia Pharmaceutica. 2009; 77(3):555-566. https://doi.org/10.3797/scipharm.0901-30

Chicago/Turabian Style

JAIN, Anurekha, and Subhash C. CHATURVEDI. 2009. "QSAR Study on 6-Substituted Benzimidazoles: An Insight into the Structural Requirement for the Angiotensin II AT1 Receptor Antagonist" Scientia Pharmaceutica 77, no. 3: 555-566. https://doi.org/10.3797/scipharm.0901-30

APA Style

JAIN, A., & CHATURVEDI, S. C. (2009). QSAR Study on 6-Substituted Benzimidazoles: An Insight into the Structural Requirement for the Angiotensin II AT1 Receptor Antagonist. Scientia Pharmaceutica, 77(3), 555-566. https://doi.org/10.3797/scipharm.0901-30

Article Metrics

Back to TopTop