Next Article in Journal
Superaugmented Pendentic Indices: Novel Topological Descriptors for QSAR/QSPR
Previous Article in Journal
Scientia Pharmaceutica, Autorenhinweise 2009
 
 
Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Synthetic Nitroimidazoles: Biological Activities and Mutagenicity Relationships

Department of Pharmaceutical Technology, National Institute of Pharmaceutical Education and Research, Sector 67, S. A. S. Nagar-160062, Punjab, India
Sci. Pharm. 2009, 77(3), 497-520; https://doi.org/10.3797/scipharm.0907-14
Submission received: 20 July 2009 / Accepted: 11 August 2009 / Published: 12 August 2009

Abstract

Parasitic and bacterial infections affecting the gastrointestinal tract represent a significant cause of morbidity and mortality worldwide. Nitroheterocyclic drugs have been available since the early 1960s for the treatment of anaerobic protozoa. The application of these drugs has widened and they are presently used to treat anaerobic pathogenic bacteria and protozoa. 5-nitroimidazoles are a well-established group of antiprotozoal and antibacterial agents that inhibit the growth of both anaerobic bacteria and certain anaerobic protozoa, such as Trichomonas vaginalis, Entamoeba histolytica and Giardia lamblia. The important antibacterial and antiprotozoal activities of nitroimidazoles are associated with reductive metabolism that has led to considerable interest in nitroimidazole reduction chemistry and the synthesis of new, highly effective drugs. The present review provides a brief account of various biological activities exhibited by synthetic nitroimidazole derivatives as well as their structure–mutagenicity relationships.
Keywords: Antibacterial; Antifungal; Antimycobacterial; Trypanocidal; Anti-HIV activity; Antileishmanial agents Antibacterial; Antifungal; Antimycobacterial; Trypanocidal; Anti-HIV activity; Antileishmanial agents

Share and Cite

MDPI and ACS Style

MITAL, A. Synthetic Nitroimidazoles: Biological Activities and Mutagenicity Relationships. Sci. Pharm. 2009, 77, 497-520. https://doi.org/10.3797/scipharm.0907-14

AMA Style

MITAL A. Synthetic Nitroimidazoles: Biological Activities and Mutagenicity Relationships. Scientia Pharmaceutica. 2009; 77(3):497-520. https://doi.org/10.3797/scipharm.0907-14

Chicago/Turabian Style

MITAL, Alka. 2009. "Synthetic Nitroimidazoles: Biological Activities and Mutagenicity Relationships" Scientia Pharmaceutica 77, no. 3: 497-520. https://doi.org/10.3797/scipharm.0907-14

APA Style

MITAL, A. (2009). Synthetic Nitroimidazoles: Biological Activities and Mutagenicity Relationships. Scientia Pharmaceutica, 77(3), 497-520. https://doi.org/10.3797/scipharm.0907-14

Article Metrics

Back to TopTop