Differential Pulse Voltammetric Determination of Loperamide in a Pharmaceutical Dosaqe Form

A. Radi; T. Elmogy

doi:10.3797/scipharm.aut-04-20

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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).

Article

9 September 2004

Differential Pulse Voltammetric Determination of Loperamide in a Pharmaceutical Dosaqe Form

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Department of Chemistry, Faculty of Science, Mansoura university, 3451 7 Dumyat, Egypt

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Sci. Pharm.2004, 72(3), 239-248;https://doi.org/10.3797/scipharm.aut-04-20

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Abstract

A voltammetric study of the oxidation of loperamide has been carried out at the glassy carbon electrode. This compound exhibited a single peak in Britton-Robinson buffer solutions of pH 5.0–11.0, with a maximum current at pH 8.0. The electrochemical oxidation of loperamide is identified as an irreversible, diffusion-controlled process. Based on this study, a simple, rapid and sensitive voltammetric method was applied, without any interference from the excipients, to the determination of the drug in a capsule dosage form.

Keywords:

Loperamide; Differential pulse voltammetry; glassy carbon electrode; electrochemical oxidation; pharmaceutical analysis

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