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Sci. Pharm.
Volume 72
Issue 3
10.3797/scipharm.aut-04-20
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Article

Differential Pulse Voltammetric Determination of Loperamide in a Pharmaceutical Dosaqe Form

by
A. Radi
* and
T. Elmogy
Department of Chemistry, Faculty of Science, Mansoura university, 3451 7 Dumyat, Egypt
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2004, 72(3), 239-248; https://doi.org/10.3797/scipharm.aut-04-20
Submission received: 4 May 2004 / Revised: 30 August 2004 / Accepted: 30 August 2004 / Published: 9 September 2004
Versions Notes

Abstract

A voltammetric study of the oxidation of loperamide has been carried out at the glassy carbon electrode. This compound exhibited a single peak in Britton-Robinson buffer solutions of pH 5.0–11.0, with a maximum current at pH 8.0. The electrochemical oxidation of loperamide is identified as an irreversible, diffusion-controlled process. Based on this study, a simple, rapid and sensitive voltammetric method was applied, without any interference from the excipients, to the determination of the drug in a capsule dosage form.
Keywords: Loperamide; Differential pulse voltammetry; glassy carbon electrode; electrochemical oxidation; pharmaceutical analysis Loperamide; Differential pulse voltammetry; glassy carbon electrode; electrochemical oxidation; pharmaceutical analysis

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MDPI and ACS Style

Radi, A.; Elmogy, T. Differential Pulse Voltammetric Determination of Loperamide in a Pharmaceutical Dosaqe Form. Sci. Pharm. 2004, 72, 239-248. https://doi.org/10.3797/scipharm.aut-04-20

AMA Style

Radi A, Elmogy T. Differential Pulse Voltammetric Determination of Loperamide in a Pharmaceutical Dosaqe Form. Scientia Pharmaceutica. 2004; 72(3):239-248. https://doi.org/10.3797/scipharm.aut-04-20

Chicago/Turabian Style

Radi, A., and T. Elmogy. 2004. "Differential Pulse Voltammetric Determination of Loperamide in a Pharmaceutical Dosaqe Form" Scientia Pharmaceutica 72, no. 3: 239-248. https://doi.org/10.3797/scipharm.aut-04-20

APA Style

Radi, A., & Elmogy, T. (2004). Differential Pulse Voltammetric Determination of Loperamide in a Pharmaceutical Dosaqe Form. Scientia Pharmaceutica, 72(3), 239-248. https://doi.org/10.3797/scipharm.aut-04-20

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