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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
Article

Comparative Bioavailabilitv Studv of Two Brands of Terbutaline Sulphate Tablets in Healthy Human Volunteers

by 1,*, 2 and 2
1
Department of Pharmaceutics, Faculty of Pharmacy, King Saud University, El Riyadh, Saudi Arabia
2
Departmenotf Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2004, 72(3), 227-237; https://doi.org/10.3797/scipharm.aut-04-19
Received: 19 April 2004 / Revised: 1 September 2004 / Accepted: 1 September 2004 / Published: 7 September 2004
The purpose of this study was to evaluate the bioavailability of locally produced 2.5 mg terbutaline sulphate tablets (brand A ) relative to a reference product, Bricanyl 2.5 mg tablets (brand 6). The study was a single dose 5 mg randomized crossover one in 15 healthy volunteers in the fasting state. Urine was collected at intervals of 24 h. Total terbutaline excreted in urine as unchanged drug and as conjugates (sulphate and glucuronide) was determined by a developed and validated HPLC method. In-vitro characteristics of both brands were similar. Based on percent of the dose excreted in urine, the oral bioavailability ranged from 33.5% to 75.8% for both brands. Statistics were applied to judge bioequivalence according to USP 24 in-vivo bioequivalence guidance. Results indicated that brand A and B were bioequivalent and hence interchangeable in medical practice.
Keywords: Terbutaline sulphate; Tablet; Bioequivalence; Urine; HPLC analysis Terbutaline sulphate; Tablet; Bioequivalence; Urine; HPLC analysis
MDPI and ACS Style

Barakat, N.S.; Khalafallah, N.M.; Khalil, S.A. Comparative Bioavailabilitv Studv of Two Brands of Terbutaline Sulphate Tablets in Healthy Human Volunteers. Sci. Pharm. 2004, 72, 227-237. https://doi.org/10.3797/scipharm.aut-04-19

AMA Style

Barakat NS, Khalafallah NM, Khalil SA. Comparative Bioavailabilitv Studv of Two Brands of Terbutaline Sulphate Tablets in Healthy Human Volunteers. Scientia Pharmaceutica. 2004; 72(3):227-237. https://doi.org/10.3797/scipharm.aut-04-19

Chicago/Turabian Style

Barakat, Nahla S., Nawal M. Khalafallah, and Said A. Khalil 2004. "Comparative Bioavailabilitv Studv of Two Brands of Terbutaline Sulphate Tablets in Healthy Human Volunteers" Scientia Pharmaceutica 72, no. 3: 227-237. https://doi.org/10.3797/scipharm.aut-04-19

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