Next Article in Journal
Medicinal used plants from India: analysis of the essential oils of Sphaeranthus indicus flowers, roots and stems with leaves
Previous Article in Journal
Contribution to the Analysis of the Volatile Constituents from some Lavender and Lavandin Cultivars Grown in Greece
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Sci. Pharm.
Volume 71
Issue 3
10.3797/scipharm.aut-03-22
scipharm-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Method Development for Separation of Active Ingredients in Cold Medicines by Micellar Electrokinetic Chromatography

by
Leena Suntornsuk
*,
Ongart Pipitharomel
and
Prapin Wilairat
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mahidol University, 447 Sri-Ayudhaya Rd., Rajathevee, Bangkok 10400, Thailand
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2003, 71(3), 235-250; https://doi.org/10.3797/scipharm.aut-03-22
Submission received: 20 November 2002 / Revised: 6 February 2003 / Accepted: 6 February 2003 / Published: 5 August 2003
Versions Notes

Abstract

Separation of nine commonly used active ingredients in cold medicines, were demonstrated by micellar electrokinetic chromatography. The ingredients included paracetamol, chlorpheniramine maleate, diphenhydramine hydrochloride, triprolidine hydrochloride, phenylpropanolamine hydrochloride, dextromethorphan hydrobromide, loratadine, aspirin and caffeine. Effects of buffer concentrations, pH, organic modifiers and capillary length were investigated. The optimum conditions were achieved in 10 mM sodium dihydrogenphosphate-sodium tetraborate buffer, pH 9.0, containing 50 mM sodium dodecyl sulfate and 28% v/v acetonitrile using the effective length of 50 cm, the separating voltage of +15 kV and the capillary temperature of 30°C. Separation of all peaks was obtained within 28.4 min with a resolution of 1.2.
Keywords: cold medicine ingredients; micellar electrokinetic chromatography (MEKC) cold medicine ingredients; micellar electrokinetic chromatography (MEKC)

Share and Cite

MDPI and ACS Style

Suntornsuk, L.; Pipitharomel, O.; Wilairat, P. Method Development for Separation of Active Ingredients in Cold Medicines by Micellar Electrokinetic Chromatography. Sci. Pharm. 2003, 71, 235-250. https://doi.org/10.3797/scipharm.aut-03-22

AMA Style

Suntornsuk L, Pipitharomel O, Wilairat P. Method Development for Separation of Active Ingredients in Cold Medicines by Micellar Electrokinetic Chromatography. Scientia Pharmaceutica. 2003; 71(3):235-250. https://doi.org/10.3797/scipharm.aut-03-22

Chicago/Turabian Style

Suntornsuk, Leena, Ongart Pipitharomel, and Prapin Wilairat. 2003. "Method Development for Separation of Active Ingredients in Cold Medicines by Micellar Electrokinetic Chromatography" Scientia Pharmaceutica 71, no. 3: 235-250. https://doi.org/10.3797/scipharm.aut-03-22

APA Style

Suntornsuk, L., Pipitharomel, O., & Wilairat, P. (2003). Method Development for Separation of Active Ingredients in Cold Medicines by Micellar Electrokinetic Chromatography. Scientia Pharmaceutica, 71(3), 235-250. https://doi.org/10.3797/scipharm.aut-03-22

Article Metrics

Back to TopTop