Svnthesis of 3-(3.5-Dioxo-[1,2,4]-oxadiazolidin-2-vl)propylphosphonic Acids

Thomas Kurz; Detlef Geffken; Claudia Wackendorff

doi:10.3797/scipharm.aut-03-06

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Article

5 April 2003

Svnthesis of 3-(3.5-Dioxo-[1,2,4]-oxadiazolidin-2-vl)propylphosphonic Acids

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Institute of Pharmacy, University of Hamburg, Bundesstrasse 45, 20146 Hamburg, Germany

Author to whom correspondence should be addressed.

Sci. Pharm.2003, 71(2), 39-49;https://doi.org/10.3797/scipharm.aut-03-06

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Abstract

Cyclic carbonylation of hydroxyureas 3 with 1,1'-carbonyldiimidazole gave 3-(3,5-dioxo-[1,2,4]oxadiazolidin-2yl)propylphosphonic acid diethyl esters 4 which were converted into the corresponding phosphonic acids 5 with bromotrimethylsilane.

Keywords:

Hydroxyureas; cyclic carbonylation; 1,2,4-oxadiazolidine-3,s-diones; phosphonic acids

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