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Volume 71
Issue 2
10.3797/scipharm.aut-03-07
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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Article

Atypisches Verhalten von Thiophenderivaten gegeniiber Reduktions- bzw. Thionierungs-Versuchen

by
T. Erker
* and
K. Trinkl
Institut fiir Pharrnazeutische Chemie der Universitat Wien. AlthanstraBe 14. A- 1090 Wien. Osterreich
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2003, 71(2), 51-56; https://doi.org/10.3797/scipharm.aut-03-07
Submission received: 23 October 2002 / Revised: 29 November 2002 / Accepted: 29 November 2002 / Published: 10 April 2003
Versions Notes

Abstract

To prepare required thiolactarns. initial experiments were done with the lactarns 1 - 3 and Lawessol reagent. However in preliminary trials. treatment of the compounds failed to give the desired molecules. Modification of the reaction conditions. paticularly with regard to the solvent and the reaction temperature. did not permit the preparation of the corresponding thiolactams. The keto function in position 6 was thought to be responsible for this atypical behaviour. Therefore. as the following step. the acetyl group in compounds 1 - 3 should be reduced to the corresponding ethyl derivatives. This reaction did not give the needed bicycles. Reduction of compounds 4 - 6 with triethylsilanel trifluoroacetic acid brought up compounds 7 - 9.
Keywords: Thieno[2.3-bJ[1.4.J pyrazines; Lawesson reagent Thieno[2.3-bJ[1.4.J pyrazines; Lawesson reagent

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MDPI and ACS Style

Erker, T.; Trinkl, K. Atypisches Verhalten von Thiophenderivaten gegeniiber Reduktions- bzw. Thionierungs-Versuchen. Sci. Pharm. 2003, 71, 51-56. https://doi.org/10.3797/scipharm.aut-03-07

AMA Style

Erker T, Trinkl K. Atypisches Verhalten von Thiophenderivaten gegeniiber Reduktions- bzw. Thionierungs-Versuchen. Scientia Pharmaceutica. 2003; 71(2):51-56. https://doi.org/10.3797/scipharm.aut-03-07

Chicago/Turabian Style

Erker, T., and K. Trinkl. 2003. "Atypisches Verhalten von Thiophenderivaten gegeniiber Reduktions- bzw. Thionierungs-Versuchen" Scientia Pharmaceutica 71, no. 2: 51-56. https://doi.org/10.3797/scipharm.aut-03-07

APA Style

Erker, T., & Trinkl, K. (2003). Atypisches Verhalten von Thiophenderivaten gegeniiber Reduktions- bzw. Thionierungs-Versuchen. Scientia Pharmaceutica, 71(2), 51-56. https://doi.org/10.3797/scipharm.aut-03-07

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