SYNTHESIS AND ANTIBACTERIAL EVALUATION OF NEW FLAVONOID DERIVATIVES FROM 4,6-DIACETYL RESORCINOL

Khan M.S.Y.; Sharma S.; Husain A.

doi:10.3797/scipharm.aut-02-27

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Article

10 September 2002

SYNTHESIS AND ANTIBACTERIAL EVALUATION OF NEW FLAVONOID DERIVATIVES FROM 4,6-DIACETYL RESORCINOL

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Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jarnia Harndard, New Delhi- 110062, India

Author to whom correspondence should be addressed.

Sci. Pharm.2002, 70(3), 287-294;https://doi.org/10.3797/scipharm.aut-02-27

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Abstract

In order to check the antibacterial potential of bischalcones derived from 4,6-diacetyl resorcinol, a number of chalcone derivatives were synthesized by condensation with appropriate aromatic aldehydes. Out of these compounds 3b-i, 4a and 4b showed a good antibacterial activity. Methylation of the two chelated hydroxyls reduced the activity. However, oxidative cyclization of 3a and 3b resulted in compounds 4a and 4b which were found to be considerably active. The alternative method of synthesis of 4a and 4b via Baker-Venkatararnan rearrangement did not succeed.

Keywords:

Flavones, bischalcones, resorcinol, antibacterial

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