Enhanced Dissolution Rate of Tiaprofenic Acid Using Gelucire®44/14*
University of Istanbul, Faculty of Pharmacy, Department of Pharmaceutical Technology, 34452-Beyazit, Istanbul, TURKEY
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2002, 70(3), 295-307; https://doi.org/10.3797/scipharm.aut-02-28
Submission received: 12 December 2001
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Revised: 29 August 2002
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Accepted: 29 August 2002
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Published: 11 September 2002
Simple Summary
Tiaprofenic acid, a water insoluble drug, was dispersed in the melted Gelucire® 44/14 at 1:1 ratio and the resulting thermosoftening solid dispersion was encapsulated into size 0 hard gelatin capsules. The release of tiaprofenic acid from capsules was evaluated by the dissolution test according to USP XXIII paddle method using distilled water and simulated gastric fluid as dissolution medium. In addition, the dissolution of hard gelatin capsules containing tiaprofenic acid dispersed in various PEGS with that of the pure drug was also investigated for comparison. The results showed that Gelucire® 44/14 was able to effect a remarkable increase in the dissolution rate of tiaprofenic acid.
Excerpt
Note: In lieu of an abstract, this is an excerpt from the first page.
Tiaprofenic acid (TA), racemic (5-benzoyl-2-thieny1)-propionic acid (Fig. 1) is a 2-aryl propionic acid derivative nonsteroidal anti-inflammatory drug (1) [...]
