Reaction of Prop-2-ynylamine with Isochromadiones : Formation of Amides

C. O. Usifoh; L. O. Okunrobo; G. C. Ukoh

doi:10.3797/scipharm.aut-01-17

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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).

Article

30 June 2001

Reaction of Prop-2-ynylamine with Isochromadiones : Formation of Amides

and

Departments of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Benin, Benin City, Nigeria

Departments of Pharmaceutical Microbiology, Faculty of Pharmacy, University of Benin, Benin City, Nigeria

Author to whom correspondence should be addressed.

Sci. Pharm.2001, 69(2), 161-166;https://doi.org/10.3797/scipharm.aut-01-17

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Abstract

The ring opening of isochromadiones by prop-2-ynylamine was accomplished in non-polar solvents to form N-prop-2-ynylbenzamide-2-acetic acid 3 N-prop-2-ynylhomophthalimide 4. Compound 3 was found out to be an intermediate product in the formation of 4. These compounds were screened for anticonvulsant and antibacterial properties and were found to have no activity.

Keywords:

Isochromadiones; Prop-2-ynylamine; Amide

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