Pyrrolizidine Alkaloids in Senecio nemorensis L. from Mongolia

Helmut Wiedenfeld; Narantuya S.; Altanchimeg D.; Erhard Roeder

doi:10.3797/scipharm.aut-00-19

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Article

20 April 2000

Pyrrolizidine Alkaloids in Senecio nemorensis L. from Mongolia

and

Pharmazeutisches Institut der Universität, An der Immenburg 4, D-53121 Bonn, Germany

Institute of Chemistry and Chemical Technology, Mongolian Academy of Science, Ulaanbaatar-51, Mongolia

Authors to whom correspondence should be addressed.

Sci. Pharm.2000, 68(2), 207-211;https://doi.org/10.3797/scipharm.aut-00-19

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Abstract

We isolated four Pyrrolizidine Alkaloids (PA) from Senecio nemorensis L. growing in Mongolia. Their structures were elucidated by spectroscopic methods to be 7-Senecioyl-9-sarracinoyl-retronecine, Retroisosenine, Doriasenine and Bulgarsenine. The alkaloidal pattern is very similar to that of the European Senecio nemorensis L., ssp. nemorensis (Rchb.) Celak. The medicinal use of this plant or of preparations from it may be hazardous to human health because of the high PA level in the plant (≈ 0.1%) and the fact that three of the PA are known to have toxic side-effects.

Keywords:

Senecio nemorensis; Mongolia; Pyrrolizidine alkaloids; 7-Senecioyl-9-sarracinoylretronecine; Retroisosenine; Doriasenine; Bulgarsenine

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