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Sci. Pharm.
Volume 68
Issue 2
10.3797/scipharm.aut-00-20
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Article

Preparation of MFP Microspheres Using Polyacrylate Resins for the Therapy of Osteoporosis

by
A. Janka
,
B. Korsatko-Wabnegg
and
W. Korsatko
*
Karl Franzens University Graz, Institute of Pharmaceutical Technology, Schubertstraße 6, 8010 Graz, Austria
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2000, 68(2), 213-221; https://doi.org/10.3797/scipharm.aut-00-20
Submission received: 10 March 2000 / Revised: 2 May 2000 / Accepted: 2 May 2000 / Published: 1 June 2000
Versions Notes

Abstract

Disodium Monofluorophoshate (MFP), a highly water soluble drug, was incorporated in polyacrylate resin microspheres by using the solvent-evaporation technique. The process is based on dispersing the acetone solution of the drug and the polymer in liquid paraffin. Eudragit RS 100/S 100 in a 3:1 ratio turned out as the best coating material. The influence of the main manufacturing factors, namely polymer-drug ratio, addition of magnesium stearate, size of the beads, production temperature and speed of stirring, on the technological characteristics of the microspheres, like release rate of the drug, shape, drug-loading and size of the particle were investigated. The findings resulted in a formulation, which obtains the desired controlled release of the drug in a convenient oral system.
Keywords: Disodium Monofluorophosphate; Osteoporosis; Solvent-evaporation technique; Controlled release; Drink suspension Disodium Monofluorophosphate; Osteoporosis; Solvent-evaporation technique; Controlled release; Drink suspension

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MDPI and ACS Style

Janka, A.; Korsatko-Wabnegg, B.; Korsatko, W. Preparation of MFP Microspheres Using Polyacrylate Resins for the Therapy of Osteoporosis. Sci. Pharm. 2000, 68, 213-221. https://doi.org/10.3797/scipharm.aut-00-20

AMA Style

Janka A, Korsatko-Wabnegg B, Korsatko W. Preparation of MFP Microspheres Using Polyacrylate Resins for the Therapy of Osteoporosis. Scientia Pharmaceutica. 2000; 68(2):213-221. https://doi.org/10.3797/scipharm.aut-00-20

Chicago/Turabian Style

Janka, A., B. Korsatko-Wabnegg, and W. Korsatko. 2000. "Preparation of MFP Microspheres Using Polyacrylate Resins for the Therapy of Osteoporosis" Scientia Pharmaceutica 68, no. 2: 213-221. https://doi.org/10.3797/scipharm.aut-00-20

APA Style

Janka, A., Korsatko-Wabnegg, B., & Korsatko, W. (2000). Preparation of MFP Microspheres Using Polyacrylate Resins for the Therapy of Osteoporosis. Scientia Pharmaceutica, 68(2), 213-221. https://doi.org/10.3797/scipharm.aut-00-20

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