Next Article in Journal
Acknowledgement to Reviewers of Cosmetics in 2017
Previous Article in Journal
Personal Care Products Are Only One of Many Exposure Routes of Natural Toxic Substances to Humans and the Environment
Article

Significance of Ubiad1 for Epidermal Keratinocytes Involves More Than CoQ10 Synthesis: Implications for Skin Aging

Ashland Specialties France, Global Skin Research Center 655 route du Pin Montard, 06904 Sophia Antipolis, France
*
Author to whom correspondence should be addressed.
Cosmetics 2018, 5(1), 9; https://doi.org/10.3390/cosmetics5010009
Received: 27 November 2017 / Revised: 2 January 2018 / Accepted: 4 January 2018 / Published: 9 January 2018
The significance of Coenzyme Q10 (CoQ10) as an anti-oxidant barrier of the skin, as well as a key component in anti-aging strategies for skin care products, has been firmly established. Biosynthesis of CoQ10 in the mitochondria is well known, but there is only limited information on the non-mitochondrial synthesis of CoQ10 in the skin. Recent findings in zebrafish identified that a tumor suppressor, Ubiad1, is also a key enzyme in the non-mitochondrial synthesis of CoQ10. The purpose of this study was to investigate expression of Ubiad1 in human skin, and its implication in the skin’s cutaneous response to oxidative stress. We observed Ubiad1 localization in the epidermis, particularly a subcellular localization in the Golgi apparatus. Ubiad1 modulation by a pentapeptide was associated with an observed reduction in ROS/RNS stresses (−44%/−19% respectively), lipid peroxidation (−25%) and preservation of membrane fluidity under stress conditions. Electron microscopy of keratinocytes revealed a significant degree of stimulation of the Golgi complex, as well as significantly improved mitochondrial morphology. Given the importance of CoQ10 in mitigating the visible signs of skin aging, our findings identify Ubiad1 as an essential component of the defensive barriers of the epidermis. View Full-Text
Keywords: skin; Ubiad1; keratinocyte; coenzyme Q10; Golgi apparatus skin; Ubiad1; keratinocyte; coenzyme Q10; Golgi apparatus
Show Figures

Figure 1

MDPI and ACS Style

Labarrade, F.; Menon, G.; Labourasse, L.; Gondran, C.; Cucumel, K.; Domloge, N. Significance of Ubiad1 for Epidermal Keratinocytes Involves More Than CoQ10 Synthesis: Implications for Skin Aging. Cosmetics 2018, 5, 9. https://doi.org/10.3390/cosmetics5010009

AMA Style

Labarrade F, Menon G, Labourasse L, Gondran C, Cucumel K, Domloge N. Significance of Ubiad1 for Epidermal Keratinocytes Involves More Than CoQ10 Synthesis: Implications for Skin Aging. Cosmetics. 2018; 5(1):9. https://doi.org/10.3390/cosmetics5010009

Chicago/Turabian Style

Labarrade, Florian, Gopinathan Menon, Laura Labourasse, Catherine Gondran, Karine Cucumel, and Nouha Domloge. 2018. "Significance of Ubiad1 for Epidermal Keratinocytes Involves More Than CoQ10 Synthesis: Implications for Skin Aging" Cosmetics 5, no. 1: 9. https://doi.org/10.3390/cosmetics5010009

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop