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The Role of Beclin 1-Dependent Autophagy in Cancer

1
Institute for Cell Biology (Tumorforschung), University Hospital Essen, 45122 Essen, Germany
2
German Cancer Consortium (DKTK) at Essen-Düsseldorf, 445122 Essen, Germany
Received: 29 November 2019 / Revised: 17 December 2019 / Accepted: 19 December 2019 / Published: 22 December 2019
(This article belongs to the Special Issue Autophagy in Cancer)
Autophagy (self-eating) is an intracellular degradation process used by cells to keep a “clean house”; as it degrades abnormal or damaged proteins and organelles, it helps to fight infections and also provides energy in times of fasting or exercising. Autophagy also plays a role in cancer, although its precise function in each cancer type is still obscure, and whether autophagy plays a protecting (through the clearing of damaged organelles and protein aggregates and preventing DNA damage) or a promoting (by fueling the already stablished tumor) role in cancer remains to be fully characterized. Beclin 1, the mammalian ortholog of yeast Atg6/Vps30, is an essential autophagy protein and has been shown to play a role in tumor suppression. Here, an update of the tumorigenesis regulation by Beclin 1-dependent autophagy is provided. View Full-Text
Keywords: Beclin 1; autophagy; cancer Beclin 1; autophagy; cancer
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MDPI and ACS Style

Vega-Rubín-de-Celis, S. The Role of Beclin 1-Dependent Autophagy in Cancer. Biology 2020, 9, 4. https://doi.org/10.3390/biology9010004

AMA Style

Vega-Rubín-de-Celis S. The Role of Beclin 1-Dependent Autophagy in Cancer. Biology. 2020; 9(1):4. https://doi.org/10.3390/biology9010004

Chicago/Turabian Style

Vega-Rubín-de-Celis, Silvia. 2020. "The Role of Beclin 1-Dependent Autophagy in Cancer" Biology 9, no. 1: 4. https://doi.org/10.3390/biology9010004

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