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Open AccessArticle

Evaluation of Experimental Multi-Particulate Polymer-Coated Drug Delivery Systems with Meloxicam

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Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 020956 Bucharest, Romania
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Department of Pharmaceutical Physics and Informatics, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 020956 Bucharest, Romania
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Department of Physical and Colloidal Chemistry, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 020956 Bucharest, Romania
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Department of Clinical Sciences no.3, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania
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Author to whom correspondence should be addressed.
Coatings 2020, 10(5), 490; https://doi.org/10.3390/coatings10050490
Received: 19 March 2020 / Revised: 10 May 2020 / Accepted: 13 May 2020 / Published: 20 May 2020
The objectives of this study are the development and evaluation of modified release multi-particulate drug delivery systems containing a BCS class II drug (meloxicam), formulated as polymer-coated pellets. Inert seeds containing microcrystalline cellulose, lactose monohydrate, and polyvinylpyrrolidone were prepared by extrusion-spheronization. The obtained cores were loaded with meloxicam using the drug layering technique, by spray coating in a fluidized bed with a liquid dispersion of the drug. The resulting drug pellets were film-coated with various polymers (Acryl-EZE® 93O, Eudragit® RS 30-D as well as experimental composite obtained by adding Methocel™ E5 Premium LV as pore forming agent to the extended release polymer Eudragit® RS 30-D). All experimental systems were evaluated by scanning electron microscopy and in vitro release testing, in an attempt to investigate the characteristics of the film coatings and their influence on drug release from the multi-particulate systems. The in vitro release study was performed in two stages, using two media with pH values corresponding to the gastric and intestinal environment (HCl 0.1N, pH = 1.2 for the first two hours of the test and phosphate buffer 50 mM, pH 6.8 for the next 4 h). The in vitro release data have highlighted the impact of the formulation factors on the drug release. View Full-Text
Keywords: pellets; drug layering; polymeric films; scanning electron microscopy; in vitro release kinetics pellets; drug layering; polymeric films; scanning electron microscopy; in vitro release kinetics
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Hîrjău, M.; Miron, D.S.; Anuța, V.; Lupuliasa, D.; Ghica, M.V.; Jinga, V.; Dinu-Pîrvu, C.-E. Evaluation of Experimental Multi-Particulate Polymer-Coated Drug Delivery Systems with Meloxicam. Coatings 2020, 10, 490.

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