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Open AccessArticle

Green Synthesis of Silver Nanoparticles and Evaluation of Their Antibacterial Activity against Multidrug-Resistant Bacteria and Wound Healing Efficacy Using a Murine Model

1
Department of Genetics and Genomics, Yogi Vemana University, Kadapa, AP 516005, India
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Department of Biotechnology and Bioinformatics, Yogi Vemana University, Kadapa, AP 516005, India
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School of Chemical and Biomolecular Engineering, The University of Sydney, Sydney, NSW 2006, Australia
4
School of Mechanical Engineering, Yeungnam University, Gyeongsan 712-749, Korea
5
Advanced Functional Materials Laboratory, Department of Applied Chemistry, Zakir Husain College of Engineering and Technology, Faculty of Engineering and Technology, Aligarh Muslim University, Aligarh, UP 202002, India
6
Deanship of Scientific Research, King Abdulaziz University, Jeddah 80216, Saudi Arabia
*
Authors to whom correspondence should be addressed.
Antibiotics 2020, 9(12), 902; https://doi.org/10.3390/antibiotics9120902
Received: 2 November 2020 / Revised: 7 December 2020 / Accepted: 10 December 2020 / Published: 13 December 2020
Green nanotechnology has significant applications in various biomedical science fields. In this study, green-synthesized silver nanoparticles, prepared by using Catharanthus roseus and Azadirachta indica extracts, were characterized using UV–Vis spectroscopy, dynamic light scattering, X-ray diffraction, scanning electron microscopy, and transmission electron microscopy. Silver nanoparticles (Ag NPs) synthesized from leaf extracts of C. roseus and A. indica effectively inhibited the growth of multidrug-resistant (MDR) bacteria isolated from patients with septic wound infections. The maximum bacteriolytic activity of the green-synthesized Ag NPs of C. roseus and A. indica against the MDR bacterium K. Pneumoniae was shown by a zone of inhibition of 19 and 16 mm, respectively. C. roseus Ag NPs exhibited more bacteriolytic activity than A. indica Ag NPs in terms of the zone of inhibition. Moreover, these particles were effective in healing wounds in BALB/c mice. Ag NPs of C. roseus and A. indica enhanced wound healing by 94% ± 1% and 87% ± 1%, respectively. Our data suggest that Ag NPs from C. roseus and A. indicia ameliorate excision wounds, and wound healing could be due to their effective antimicrobial activity against MDR bacteria. Hence, these Ag NPs could be potential therapeutic agents for the treatment of wounds. View Full-Text
Keywords: silver nanoparticles; green synthesis method; Catharanthus roseus; Azadirachta indica; multidrug-resistant bacteria; wound healing silver nanoparticles; green synthesis method; Catharanthus roseus; Azadirachta indica; multidrug-resistant bacteria; wound healing
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MDPI and ACS Style

Lakkim, V.; Reddy, M.C.; Pallavali, R.R.; Reddy, K.R.; Reddy, C.V.; Inamuddin; Bilgrami, A.L.; Lomada, D. Green Synthesis of Silver Nanoparticles and Evaluation of Their Antibacterial Activity against Multidrug-Resistant Bacteria and Wound Healing Efficacy Using a Murine Model. Antibiotics 2020, 9, 902. https://doi.org/10.3390/antibiotics9120902

AMA Style

Lakkim V, Reddy MC, Pallavali RR, Reddy KR, Reddy CV, Inamuddin, Bilgrami AL, Lomada D. Green Synthesis of Silver Nanoparticles and Evaluation of Their Antibacterial Activity against Multidrug-Resistant Bacteria and Wound Healing Efficacy Using a Murine Model. Antibiotics. 2020; 9(12):902. https://doi.org/10.3390/antibiotics9120902

Chicago/Turabian Style

Lakkim, Vajravathi; Reddy, Madhava C.; Pallavali, Roja R.; Reddy, Kakarla R.; Reddy, Ch V.; Inamuddin; Bilgrami, Anwar L.; Lomada, Dakshayani. 2020. "Green Synthesis of Silver Nanoparticles and Evaluation of Their Antibacterial Activity against Multidrug-Resistant Bacteria and Wound Healing Efficacy Using a Murine Model" Antibiotics 9, no. 12: 902. https://doi.org/10.3390/antibiotics9120902

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