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Open AccessArticle

Inhibition of Bacterial and Fungal Biofilm Formation by 675 Extracts from Microalgae and Cyanobacteria

ISGlobal, Hospital Clínic—Universitat de Barcelona, 08036 Barcelona, Spain
Coimbra Collection of Algae (ACOI), Department of Life Sciences, University of Coimbra, 3000-456 Coimbra, Portugal
Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), 4450-208 Porto, Portugal
Faculty of Sciences, University of Porto, 4450-208 Porto, Portugal
Roscoff Culture Collection, Sorbonne University/CNRS, Roscoff Biological Station, 29680 Roscoff, France
Marine Natural Products Team, Nice Institute of Chemistry, UMR 7272 University Nice Côte d’Azur/CNRS, 60103 Nice, France
Author to whom correspondence should be addressed.
Antibiotics 2019, 8(2), 77;
Received: 13 May 2019 / Revised: 3 June 2019 / Accepted: 5 June 2019 / Published: 12 June 2019
(This article belongs to the Special Issue Marine Antimicrobials)
Bacterial biofilms are complex biological systems that are difficult to eradicate at a medical, industrial, or environmental level. Biofilms confer bacteria protection against external factors and antimicrobial treatments. Taking into account that about 80% of human infections are caused by bacterial biofilms, the eradication of these structures is a great priority. Biofilms are resistant to old-generation antibiotics, which has led to the search for new antimicrobials from different sources, including deep oceans/seas. In this study, 675 extracts obtained from 225 cyanobacteria and microalgae species (11 phyla and 6 samples belonging to unknown group) were obtained from different culture collections: The Blue Biotechnology and Ecotoxicology Culture Collection (LEGE-CC), the Coimbra Collection of Algae (ACOI) from Portugal, and the Roscoff Culture Collection (RCC) from France. The largest number of samples was made up of the microalgae phylum Chlorophyta (270) followed by Cyanobacteria (261). To obtain a large range of new bioactive compounds, a method involving three consecutive extractions (hexane, ethyl acetate, and methanol) was used. The antibiofilm activity of extracts was determined against seven different bacterial species and two Candida strains in terms of minimal biofilm inhibitory concentration (MBIC). The highest biofilm inhibition rates (%) were achieved against Candida albicans and Enterobacter cloacae. Charophyta, Chlorophyta, and Cyanobacteria were the most effective against all microorganisms. In particular, extracts of Cercozoa phylum presented the lowest MBIC50 and MBIC90 values for all the strains except C. albicans. View Full-Text
Keywords: Marine sources; Microalgae; Cyanobacteria; Antibiofilm Marine sources; Microalgae; Cyanobacteria; Antibiofilm
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MDPI and ACS Style

Cepas, V.; López, Y.; Gabasa, Y.; Martins, C.B.; Ferreira, J.D.; Correia, M.J.; Santos, L.M.A.; Oliveira, F.; Ramos, V.; Reis, M.; Castelo-Branco, R.; Morais, J.; Vasconcelos, V.; Probert, I.; Guilloud, E.; Mehiri, M.; Soto, S.M. Inhibition of Bacterial and Fungal Biofilm Formation by 675 Extracts from Microalgae and Cyanobacteria. Antibiotics 2019, 8, 77.

AMA Style

Cepas V, López Y, Gabasa Y, Martins CB, Ferreira JD, Correia MJ, Santos LMA, Oliveira F, Ramos V, Reis M, Castelo-Branco R, Morais J, Vasconcelos V, Probert I, Guilloud E, Mehiri M, Soto SM. Inhibition of Bacterial and Fungal Biofilm Formation by 675 Extracts from Microalgae and Cyanobacteria. Antibiotics. 2019; 8(2):77.

Chicago/Turabian Style

Cepas, Virginio; López, Yuly; Gabasa, Yaiza; Martins, Clara B.; Ferreira, Joana D.; Correia, Maria J.; Santos, Lília M.A.; Oliveira, Flávio; Ramos, Vitor; Reis, Mariana; Castelo-Branco, Raquel; Morais, João; Vasconcelos, Vitor; Probert, Ian; Guilloud, Emilie; Mehiri, Mohamed; Soto, Sara M. 2019. "Inhibition of Bacterial and Fungal Biofilm Formation by 675 Extracts from Microalgae and Cyanobacteria" Antibiotics 8, no. 2: 77.

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