Natural and Enantiopure Alkylglycerols as Antibiofilms Against Clinical Bacterial Isolates and Quorum Sensing Inhibitors of Chromobacterium violaceum ATCC 12472
Abstract
:1. Introduction
2. Results
2.1. Structures of Natural and Enantiopure Alkylglycerols
2.2. Minimal Inhibitory Concentration (MIC) of Alkylglycerols
2.3. Alkylglycerols Ability to Inhibit of Biofilm Formation
2.4. Quorum Sensing Inhibition Activity of Natural Alkylglycerols
3. Discussion
4. Materials and Methods
4.1. General
4.1.1. Screened Compounds
4.1.2. Bacterial Strains and Culture Conditions
4.2. Determination of the Minimum Inhibitory Concentration of Screened Compounds
4.3. Effectiveness of Alkylglycerols on the Inhibition of Biofilm Formation
4.4. Screening for Quorum Sensing Inhibition Activity
4.5. Statistical Analysis
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Strains | Alkylglycerols a | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
CPX b | 2 | 3 | 4 | 5 | 6 | 7 | 9 | 10 | 11 | |
K. pneumoniae 792 | 0.09 | >1224 | >1076 | >960 | >867 | >790 | >795 | >730 | >734 | >738 |
E. cloacae 250 | 48.2 | >1224 | >1076 | >960 | >867 | 395 | >795 | >730 | >734 | >738 |
E. coli 667 | 0.09 | >1224 | >1076 | >960 | >867 | >790 | >795 | >730 | >734 | >738 |
P. aeruginosa 740 | 1.51 | >1224 | >1076 | >960 | >867 | >790 | >795 | >730 | >734 | >738 |
P. mirabilis 26 | 0.09 | >1224 | 1076 | >960 | >867 | >790 | >795 | >730 | >734 | >738 |
C. violaceum ATCC 12472 | 0.18 | >1224 | 269 | >960 | >867 | >790 | >795 | 730 | >734 | >738 |
E. faecalis 12 | 0.51 | >1224 | 538 | 119 | 433 | >790 | 199 | 365 | 734 | >738 |
E. gallinarum 662 | 48.2 | >1224 | >1076 | 119 | >867 | >790 | >795 | >730 | >734 | >738 |
S. epidermidis ATCC 12228 | 0.39 | >1224 | 538 | 119 | 108 | >790 | 795 | >730 | 734 | >738 |
S. aureus ATCC 6538 | 0.18 | 612 | 67 | 30 | 27 | >790 | 99 | >730 | 367 | 369 |
Values. µM a | Alkylglycerols | ||||||||||||||
1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | |
709 | 611 | 135 | 120 | 109 | 197 | 795 | 363 | 365 | 92 | 369 | 335 | 337 | 312 | 20 |
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Chaverra Daza, K.E.; Silva Gómez, E.; Moreno Murillo, B.D.; Mayorga Wandurraga, H. Natural and Enantiopure Alkylglycerols as Antibiofilms Against Clinical Bacterial Isolates and Quorum Sensing Inhibitors of Chromobacterium violaceum ATCC 12472. Antibiotics 2021, 10, 430. https://doi.org/10.3390/antibiotics10040430
Chaverra Daza KE, Silva Gómez E, Moreno Murillo BD, Mayorga Wandurraga H. Natural and Enantiopure Alkylglycerols as Antibiofilms Against Clinical Bacterial Isolates and Quorum Sensing Inhibitors of Chromobacterium violaceum ATCC 12472. Antibiotics. 2021; 10(4):430. https://doi.org/10.3390/antibiotics10040430
Chicago/Turabian StyleChaverra Daza, Klauss E., Edelberto Silva Gómez, Bárbara D. Moreno Murillo, and Humberto Mayorga Wandurraga. 2021. "Natural and Enantiopure Alkylglycerols as Antibiofilms Against Clinical Bacterial Isolates and Quorum Sensing Inhibitors of Chromobacterium violaceum ATCC 12472" Antibiotics 10, no. 4: 430. https://doi.org/10.3390/antibiotics10040430