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Biosensors 2018, 8(4), 107; https://doi.org/10.3390/bios8040107

Raman Spectroscopy and Microscopy Applications in Cardiovascular Diseases: From Molecules to Organs

Department of Mechanical and Industrial Engineering, Louisiana State University, Baton Rouge, LA 70803, USA
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Received: 25 October 2018 / Revised: 7 November 2018 / Accepted: 7 November 2018 / Published: 12 November 2018
(This article belongs to the Special Issue Applications of Raman Techniques in Biosensing)
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Abstract

Noninvasive and label-free vibrational spectroscopy and microscopy methods have shown great potential for clinical diagnosis applications. Raman spectroscopy is based on inelastic light scattering due to rotational and vibrational modes of molecular bonds. It has been shown that Raman spectra provide chemical signatures of changes in biological tissues in different diseases, and this technique can be employed in label-free monitoring and clinical diagnosis of several diseases, including cardiovascular studies. However, there are very few literature reviews available to summarize the state of art and future applications of Raman spectroscopy in cardiovascular diseases, particularly cardiac hypertrophy. In addition to conventional clinical approaches such as electrocardiography (ECG), echocardiogram (cardiac ultrasound), positron emission tomography (PET), cardiac computed tomography (CT), and single photon emission computed tomography (SPECT), applications of vibrational spectroscopy and microscopy will provide invaluable information useful for the prevention, diagnosis, and treatment of cardiovascular diseases. Various in vivo and ex vivo investigations can potentially be performed using Raman imaging to study and distinguish pathological and physiological cardiac hypertrophies and understand the mechanisms of other cardiac diseases. Here, we have reviewed the recent literature on Raman spectroscopy to study cardiovascular diseases covering investigations on the molecular, cellular, tissue, and organ level. View Full-Text
Keywords: Raman imaging; vibrational spectroscopy; cardiovascular disease; cardiac hypertrophy; cardiac biomarkers Raman imaging; vibrational spectroscopy; cardiovascular disease; cardiac hypertrophy; cardiac biomarkers
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Chaichi, A.; Prasad, A.; Gartia, M.R. Raman Spectroscopy and Microscopy Applications in Cardiovascular Diseases: From Molecules to Organs. Biosensors 2018, 8, 107.

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