Next Article in Journal
Synthesis of Ni3Si4O10(OH)2 Porous Microspheres as Support of Pd Catalyst for Hydrogenation Reaction
Previous Article in Journal
Fe3O4 Hollow Nanosphere-Coated Spherical-Graphite Composites: A High-Rate Capacity and Ultra-Long Cycle Life Anode Material for Lithium Ion Batteries
Article Menu

Export Article

Open AccessArticle

Lignin-Based Hollow Nanoparticles for Controlled Drug Delivery: Grafting Preparation Using β-Cyclodextrin/Enzymatic-Hydrolysis Lignin

1
Research Institute of Wood Industry, Chinese Academy of Forestry, Xiangshan Road, Beijing 100089, China
2
School of Chemistry and Chemical Engineering, Yancheng Institute of Technology, Yancheng City 224051, China
*
Authors to whom correspondence should be addressed.
Nanomaterials 2019, 9(7), 997; https://doi.org/10.3390/nano9070997
Received: 6 May 2019 / Revised: 26 June 2019 / Accepted: 1 July 2019 / Published: 11 July 2019
  |  
PDF [2663 KB, uploaded 11 July 2019]
  |  

Abstract

Due to its abundance, degradability, and low toxicity, lignin is a promising raw material for the preparation of nanomaterials. However, efficient encapsulation using lignin-nanomaterial for sustained-release medications remains a challenge. This study involves grafting β-cyclodextrin (β-CD), with a hollow toroidal structure, onto the enzymatic-hydrolysis lignin (EHL) to form CD-EHL. The modified lignin was next used to prepare hollow nanoparticles (LHNPs) via self-assembly to encapsulate the antitumor drug hydroxycamptothecin (HCPT). The results indicated that β-CD improved the network structure of modified lignin molecules. Moreover, LHNPs that self-assembled using CD-EHL had an increased specific surface area and greater porosity, and exhibited a spherical hollow structure and stability in phosphate-buffered saline. The drug loading and encapsulation efficiency of HCPT were 70.6 ± 9% and 22.02 ± 2%, respectively. An in vitro study showed that lignin-based nanoparticles have low toxicity, and the modified LHNPs demonstrated a good sustained-release capability. This study broadened the potential application of lignin as a renewable biomass material. View Full-Text
Keywords: lignin; β-cyclodextrin; hollow nanoparticles; hydroxycamptothecin; sustained release lignin; β-cyclodextrin; hollow nanoparticles; hydroxycamptothecin; sustained release
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Zhou, Y.; Han, Y.; Li, G.; Yang, S.; Chu, F. Lignin-Based Hollow Nanoparticles for Controlled Drug Delivery: Grafting Preparation Using β-Cyclodextrin/Enzymatic-Hydrolysis Lignin. Nanomaterials 2019, 9, 997.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nanomaterials EISSN 2079-4991 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top