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Large-Scale Fabrication of Nanostructure on Bio-Metallic Substrate for Surface Enhanced Raman and Fluorescence Scattering

1
School of Mechanical Engineering & Automation, Beihang University, Beijing 100191, China
2
School of Mechanical and Aerospace, Nanyang Technological University, Singapore 639798, Singapore
3
National Engineering Laboratory of Additive Manufacturing for Large Metallic Components, Beihang University, Beijing 100191, China
4
Hefei Innovation Research Institute of Beihang University, Xinzhan Hi-tech District, Hefei 230013, China
*
Authors to whom correspondence should be addressed.
Nanomaterials 2019, 9(7), 916; https://doi.org/10.3390/nano9070916
Received: 9 May 2019 / Revised: 1 June 2019 / Accepted: 10 June 2019 / Published: 26 June 2019
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Abstract

The integration of surface-enhanced Raman scattering (SERS) and surface-enhanced fluorescence (SEF) has attracted increasing interest and is highly probable to improve the sensitivity and reproducibility of spectroscopic investigations in biomedical fields. In this work, dual-mode SERS and SEF hierarchical structures have been developed on a single bio-metallic substrate. The hierarchical structure was composed of micro-grooves, nano-particles, and nano-ripples. The crystal violet was selected as reporter molecule and both the intensity of Raman and fluorescence signals were enhanced because of the dual-mode SERS−SEF phenomena with enhancement factors (EFs) of 7.85 × 105 and 14.32, respectively. The Raman and fluorescence signals also exhibited good uniformity with the relative standard deviation value of 2.46% and 5.15%, respectively. Moreover, the substrate exhibited high sensitivity with the limits of detection (LOD) as low as 1 × 10−11 mol/L using Raman spectroscopy and 1 × 10−10 mol/L by fluorescence spectroscopy. The combined effect of surface plasmon resonance and “hot spots” induced by the hierarchical laser induced periodical surface structures (LIPSS) was mainly contributed to the enhancement of Raman and fluorescence signal. We propose that the integration of SERS and SEF in a single bio-metallic substrate is promising to improve the sensitivity and reproducibility of detection in biomedical investigations. View Full-Text
Keywords: hierarchical LIPSS; surface-enhanced Raman scattering; surface-enhanced fluorescence; bio-metallic substrate; crystal violet hierarchical LIPSS; surface-enhanced Raman scattering; surface-enhanced fluorescence; bio-metallic substrate; crystal violet
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Lu, L.; Zhang, J.; Jiao, L.; Guan, Y. Large-Scale Fabrication of Nanostructure on Bio-Metallic Substrate for Surface Enhanced Raman and Fluorescence Scattering. Nanomaterials 2019, 9, 916.

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