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Open AccessArticle

Photothermally Controlled Methotrexate Release System Using β-Cyclodextrin and Gold Nanoparticles

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Department of Chemistry, University of Chile, Las Palmeras 3425, 7800003 Santiago, Chile
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Department of Chemistry of Materials, University of Santiago de Chile, Av. Libertador Bernardo O’Higgins 3363, 9170022 Santiago, Chile
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Department of Pharmacological and Toxicological Chemistry, University of Chile, Sergio Livingston 1007, 8380492 Santiago, Chile
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Advanced Center for Chronic Diseases (ACCDiS), University of Chile, Sergio Livingstone 1007, 8380000 Independencia Santiago, Chile
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Department of Biology, CEM, University of Chile, Las Palmeras 3425, 7800003 Santiago, Chile
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Department of Physics, University of Chile, Beauchef 850, 8370448 Santiago, Chile
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Nanobioengineering Laboratory, Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST) Baldiri Reixac, 10–12, 08028 Barcelona, Spain
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Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Monforte de Lemos 3–5, Pabellón 11, 28029 Madrid, Spain
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Department of Electronics and Biomedical Engineering, University of Barcelona (UB), Martí I Franques, 1, 08028 Barcelona, Spain
*
Authors to whom correspondence should be addressed.
Nanomaterials 2018, 8(12), 985; https://doi.org/10.3390/nano8120985
Received: 2 October 2018 / Revised: 22 November 2018 / Accepted: 22 November 2018 / Published: 28 November 2018
The inclusion compound (IC) of cyclodextrin (CD) containing the antitumor drug Methotrexate (MTX) as a guest molecule was obtained to increase the solubility of MTX and decrease its inherent toxic effects in nonspecific cells. The IC was conjugated with gold nanoparticles (AuNPs), obtained by a chemical method, creating a ternary intelligent delivery system for MTX molecules, based on the plasmonic properties of the AuNPs. Irradiation of the ternary system, with a laser wavelength tunable with the corresponding surface plasmon of AuNPs, causes local energy dissipation, producing the controlled release of the guest from CD cavities. Finally, cell viability was evaluated using MTS assays for β-CD/MTX and AuNPs + β-CD/MTX samples, with and without irradiation, against HeLa tumor cells. The irradiated sample of the ternary system AuNPs + β-CD/MTX produced a diminution in cell viability attributed to the photothermal release of MTX. View Full-Text
Keywords: inclusion compound; cyclodextrin; Methotrexate; delivery system; gold nanoparticles; photothermal release; laser; irradiation inclusion compound; cyclodextrin; Methotrexate; delivery system; gold nanoparticles; photothermal release; laser; irradiation
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MDPI and ACS Style

Silva, N.; Riveros, A.; Yutronic, N.; Lang, E.; Chornik, B.; Guerrero, S.; Samitier, J.; Jara, P.; Kogan, M.J. Photothermally Controlled Methotrexate Release System Using β-Cyclodextrin and Gold Nanoparticles. Nanomaterials 2018, 8, 985.

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