Next Article in Journal
A Label-Free Microelectrode Array Based on One-Step Synthesis of Chitosan–Multi-Walled Carbon Nanotube–Thionine for Ultrasensitive Detection of Carcinoembryonic Antigen
Next Article in Special Issue
Distribution of Iron Oxide Core-Titanium Dioxide Shell Nanoparticles in VX2 Tumor Bearing Rabbits Introduced by Two Different Delivery Modalities
Previous Article in Journal
Nanostructures Derived from Starch and Chitosan for Fluorescence Bio-Imaging
Previous Article in Special Issue
Soft Interaction in Liposome Nanocarriers for Therapeutic Drug Delivery
Open AccessReview

Lipid Nanovectors to Deliver RNA Oligonucleotides in Cancer

Department of Pharmacy, University Federico II of Naples, Via Domenico Montesano 49, 80131 Naples, Italy
Institute of Molecular Sciences, CNRS, Université Paris-Sud, Université Paris Saclay, 91400 Orsay, France
Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, 80138 Naples, Italy
Author to whom correspondence should be addressed.
Academic Editor: Luigi Pasqua
Nanomaterials 2016, 6(7), 131;
Received: 4 May 2016 / Revised: 16 June 2016 / Accepted: 1 July 2016 / Published: 9 July 2016
(This article belongs to the Special Issue Nanomaterials for Cancer Therapies)
The growing knowledge on the mechanisms of gene silencing and gene regulation by non-coding RNAs (ncRNA), mainly small interfering RNA (siRNA) and microRNA (miRNA), is providing a significant boost to the development of new therapeutic strategies for the treatment of cancer. However, the design of RNA-based therapeutics is hampered by biopharmaceutical issues, thus requiring the use of suitable delivery strategies. In this regards, lipid nanovectors have been successfully investigated to deliver RNA in different forms of cancer. Compared to other biomaterials, lipids offer advantages such as biocompatibility, biodegradability, easy production, low cost, limited toxicity and immunogenicity. The possibility to formulate these materials in the form of nanovectors allows overcoming biopharmaceutical issues associated to the therapeutic use of RNA, with the possibility to target tumors. This review takes stock of the main lipid nanovectors proposed to deliver ncRNA. For each considered delivery strategy, the rational design and the most meaningful in vitro and in vivo results are reported and discussed. View Full-Text
Keywords: nucleic acid; cationic liposomes; stable nucleic acid lipid particles (SNALPs); lipid-nanoparticles; micelles nucleic acid; cationic liposomes; stable nucleic acid lipid particles (SNALPs); lipid-nanoparticles; micelles
Show Figures

Figure 1

MDPI and ACS Style

Campani, V.; Salzano, G.; Lusa, S.; De Rosa, G. Lipid Nanovectors to Deliver RNA Oligonucleotides in Cancer. Nanomaterials 2016, 6, 131.

AMA Style

Campani V, Salzano G, Lusa S, De Rosa G. Lipid Nanovectors to Deliver RNA Oligonucleotides in Cancer. Nanomaterials. 2016; 6(7):131.

Chicago/Turabian Style

Campani, Virginia; Salzano, Giuseppina; Lusa, Sara; De Rosa, Giuseppe. 2016. "Lipid Nanovectors to Deliver RNA Oligonucleotides in Cancer" Nanomaterials 6, no. 7: 131.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop