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Open AccessReview

Lipid Nanovectors to Deliver RNA Oligonucleotides in Cancer

1
Department of Pharmacy, University Federico II of Naples, Via Domenico Montesano 49, 80131 Naples, Italy
2
Institute of Molecular Sciences, CNRS, Université Paris-Sud, Université Paris Saclay, 91400 Orsay, France
3
Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, 80138 Naples, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Luigi Pasqua
Nanomaterials 2016, 6(7), 131; https://doi.org/10.3390/nano6070131
Received: 4 May 2016 / Revised: 16 June 2016 / Accepted: 1 July 2016 / Published: 9 July 2016
(This article belongs to the Special Issue Nanomaterials for Cancer Therapies)
The growing knowledge on the mechanisms of gene silencing and gene regulation by non-coding RNAs (ncRNA), mainly small interfering RNA (siRNA) and microRNA (miRNA), is providing a significant boost to the development of new therapeutic strategies for the treatment of cancer. However, the design of RNA-based therapeutics is hampered by biopharmaceutical issues, thus requiring the use of suitable delivery strategies. In this regards, lipid nanovectors have been successfully investigated to deliver RNA in different forms of cancer. Compared to other biomaterials, lipids offer advantages such as biocompatibility, biodegradability, easy production, low cost, limited toxicity and immunogenicity. The possibility to formulate these materials in the form of nanovectors allows overcoming biopharmaceutical issues associated to the therapeutic use of RNA, with the possibility to target tumors. This review takes stock of the main lipid nanovectors proposed to deliver ncRNA. For each considered delivery strategy, the rational design and the most meaningful in vitro and in vivo results are reported and discussed. View Full-Text
Keywords: nucleic acid; cationic liposomes; stable nucleic acid lipid particles (SNALPs); lipid-nanoparticles; micelles nucleic acid; cationic liposomes; stable nucleic acid lipid particles (SNALPs); lipid-nanoparticles; micelles
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MDPI and ACS Style

Campani, V.; Salzano, G.; Lusa, S.; De Rosa, G. Lipid Nanovectors to Deliver RNA Oligonucleotides in Cancer. Nanomaterials 2016, 6, 131. https://doi.org/10.3390/nano6070131

AMA Style

Campani V, Salzano G, Lusa S, De Rosa G. Lipid Nanovectors to Deliver RNA Oligonucleotides in Cancer. Nanomaterials. 2016; 6(7):131. https://doi.org/10.3390/nano6070131

Chicago/Turabian Style

Campani, Virginia; Salzano, Giuseppina; Lusa, Sara; De Rosa, Giuseppe. 2016. "Lipid Nanovectors to Deliver RNA Oligonucleotides in Cancer" Nanomaterials 6, no. 7: 131. https://doi.org/10.3390/nano6070131

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Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

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