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Antitumor Activities of Metal Oxide Nanoparticles

Physiology Department, Faculty of Pharmacy, Universitat de Barcelona, Av. Joan XXIII s/n, 08028 Barcelona, Spain
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Robert Tanguay
Nanomaterials 2015, 5(2), 1004-1021;
Received: 4 May 2015 / Revised: 2 June 2015 / Accepted: 4 June 2015 / Published: 9 June 2015
(This article belongs to the Special Issue Advancements in Nanotoxicology)
Nanoparticles have received much attention recently due to their use in cancer therapy. Studies have shown that different metal oxide nanoparticles induce cytotoxicity in cancer cells, but not in normal cells. In some cases, such anticancer activity has been demonstrated to hold for the nanoparticle alone or in combination with different therapies, such as photocatalytic therapy or some anticancer drugs. Zinc oxide nanoparticles have been shown to have this activity alone or when loaded with an anticancer drug, such as doxorubicin. Other nanoparticles that show cytotoxic effects on cancer cells include cobalt oxide, iron oxide and copper oxide. The antitumor mechanism could work through the generation of reactive oxygen species or apoptosis and necrosis, among other possibilities. Here, we review the most significant antitumor results obtained with different metal oxide nanoparticles. View Full-Text
Keywords: antitumor; cancer therapy; metal oxide nanoparticles; in vitro; in vivo antitumor; cancer therapy; metal oxide nanoparticles; in vitro; in vivo
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MDPI and ACS Style

Vinardell, M.P.; Mitjans, M. Antitumor Activities of Metal Oxide Nanoparticles. Nanomaterials 2015, 5, 1004-1021.

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