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Reducing X-Ray Induced Oxidative Damages in Fibroblasts with Graphene Oxide

Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA 01609, USA
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Nanomaterials 2014, 4(2), 522-534; https://doi.org/10.3390/nano4020522
Received: 1 April 2014 / Revised: 17 June 2014 / Accepted: 19 June 2014 / Published: 24 June 2014
(This article belongs to the Special Issue Nanotoxicology)
A major issue of X-ray radiation therapy is that normal cells can be damaged, limiting the amount of X-rays that can be safely delivered to a tumor. This paper describes a new method based on graphene oxide (GO) to protect normal cells from oxidative damage by removing free radicals generated by X-ray radiation using grapheme oxide (GO). A variety of techniques such as cytotoxicity, genotoxicity, oxidative assay, apoptosis, γ-H2AX expression, and micro-nucleus assay have been used to assess the protective effect of GO in cultured fibroblast cells. It is found that although GO at higher concentration (100 and 500 µg/mL) can cause cell death and DNA damage, it can effectively remove oxygen free radicals at a lower concentration of 10 µg/mL. The level of DNA damage and cell death is reduced by 48%, and 39%, respectively. Thus, low concentration GO can be used as an effective radio-protective agent in occupational and therapeutic settings. View Full-Text
Keywords: X-ray; graphene oxide; DNA damage; oxidative; reactive oxygen species (ROS) X-ray; graphene oxide; DNA damage; oxidative; reactive oxygen species (ROS)
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Qiao, Y.; Zhang, P.; Wang, C.; Ma, L.; Su, M. Reducing X-Ray Induced Oxidative Damages in Fibroblasts with Graphene Oxide. Nanomaterials 2014, 4, 522-534.

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