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Biological Effects of Clinically Relevant CoCr Nanoparticles in the Dura Mater: An Organ Culture Study

Carbon Nanotubes and Chronic Granulomatous Disease

Division of Pulmonary, Critical Care and Sleep Medicine, East Carolina University, Brody Medical Sciences Building, 600 Moye Blvd. Rm. 3E-149, Greenville, NC 27834, USA
Division of Pulmonary and Critical Care Medicine, Albany Medical College, MC-91, 47 New Scotland Avenue, Albany, NY 12208, USA
Author to whom correspondence should be addressed.
Nanomaterials 2014, 4(2), 508-521;
Received: 4 April 2014 / Revised: 15 May 2014 / Accepted: 12 June 2014 / Published: 23 June 2014
(This article belongs to the Special Issue Nanotoxicology)
Use of nanomaterials in manufactured consumer products is a rapidly expanding industry and potential toxicities are just beginning to be explored. Combustion-generated multiwall carbon nanotubes (MWCNT) or nanoparticles are ubiquitous in non-manufacturing environments and detectable in vapors from diesel fuel, methane, propane, and natural gas. In experimental animal models, carbon nanotubes have been shown to induce granulomas or other inflammatory changes. Evidence suggesting potential involvement of carbon nanomaterials in human granulomatous disease, has been gathered from analyses of dusts generated in the World Trade Center disaster combined with epidemiological data showing a subsequent increase in granulomatous disease of first responders. In this review we will discuss evidence for similarities in the pathophysiology of carbon nanotube-induced pulmonary disease in experimental animals with that of the human granulomatous disease, sarcoidosis. View Full-Text
Keywords: carbon nanotubes; sarcoidosis; alveolar macrophages carbon nanotubes; sarcoidosis; alveolar macrophages
MDPI and ACS Style

Barna, B.P.; Judson, M.A.; Thomassen, M.J. Carbon Nanotubes and Chronic Granulomatous Disease. Nanomaterials 2014, 4, 508-521.

AMA Style

Barna BP, Judson MA, Thomassen MJ. Carbon Nanotubes and Chronic Granulomatous Disease. Nanomaterials. 2014; 4(2):508-521.

Chicago/Turabian Style

Barna, Barbara P., Marc A. Judson, and Mary J. Thomassen. 2014. "Carbon Nanotubes and Chronic Granulomatous Disease" Nanomaterials 4, no. 2: 508-521.

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