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Article

Preparation of a Hydrogel Nanofiber Wound Dressing

1
Department of Nonwovens and Nanofibrous Materials, Faculty of Textile Engineering, Technical University of Liberec, 461 17 Liberec, Czech Republic
2
Department of Material Engineering, Faculty of Textile Engineering, Technical University of Liberec, 461 17 Liberec, Czech Republic
*
Author to whom correspondence should be addressed.
Academic Editor: Dipak K. Sarker
Nanomaterials 2021, 11(9), 2178; https://doi.org/10.3390/nano11092178
Received: 20 July 2021 / Revised: 23 August 2021 / Accepted: 24 August 2021 / Published: 25 August 2021
The study addressed the production of a hydrogel nanofiber skin cover and included the fabrication of hydrogel nanofibers from a blend of polyvinyl alcohol and alginate. The resulting fibrous layer was then crosslinked with glutaraldehyde, and, after 4 h of crosslinking, although the gelling component, i.e., the alginate, crosslinked, the polyvinyl alcohol failed to do so. The experiment included the comparison of the strength and ductility of the layers before and after crosslinking. It was determined that the fibrous layer following crosslinking evinced enhanced mechanical properties, which acted to facilitate the handling of the material during its application. The subsequent testing procedure proved that the fibrous layer was not cytotoxic. The study further led to the production of a modified hydrogel nanofiber layer that combined polyvinyl alcohol with alginate and albumin. The investigation of the fibrous layers produced determined that following contact with water the polyvinyl alcohol dissolved leading to the release of the albumin accompanied by the swelling of the alginate and the formation of a hydrogel. View Full-Text
Keywords: hydrogel; nanofibers; skin cover; alginate; polyvinyl alcohol hydrogel; nanofibers; skin cover; alginate; polyvinyl alcohol
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MDPI and ACS Style

Jirkovec, R.; Samkova, A.; Kalous, T.; Chaloupek, J.; Chvojka, J. Preparation of a Hydrogel Nanofiber Wound Dressing. Nanomaterials 2021, 11, 2178. https://doi.org/10.3390/nano11092178

AMA Style

Jirkovec R, Samkova A, Kalous T, Chaloupek J, Chvojka J. Preparation of a Hydrogel Nanofiber Wound Dressing. Nanomaterials. 2021; 11(9):2178. https://doi.org/10.3390/nano11092178

Chicago/Turabian Style

Jirkovec, Radek, Alzbeta Samkova, Tomas Kalous, Jiri Chaloupek, and Jiri Chvojka. 2021. "Preparation of a Hydrogel Nanofiber Wound Dressing" Nanomaterials 11, no. 9: 2178. https://doi.org/10.3390/nano11092178

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