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Challenges, Volume 9, Issue 1

June 2018 - 25 articles

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Articles (25)

  • Review
  • Open Access
12 Citations
6,670 Views
24 Pages

Poly-ADP-ribosylation is a post-translational modification that occurs in multicellular organisms, including plants and some lower unicellular eukaryotes. The founding member of the PARP family is PARP1. To date, 17 members of the PARP family have be...

  • Article
  • Open Access
5 Citations
10,180 Views
15 Pages

Lightweight Design and Welding Manufacturing of a Hydrogen Fuel Cell Powered Car’s Chassis

  • Evangelos Ch. Tsirogiannis,
  • Gerasimos I. Siasos,
  • Georgios E. Stavroulakis and
  • Sofoklis S. Makridis

The development of the chassis for the hydrogen fuel cell powered car has been involved in the designing and manufacturing aspects, while taking into consideration the mass, strength, stiffness, centre of gravity (COG), and manufacturing cost require...

  • Review
  • Open Access
1 Citations
5,811 Views
15 Pages

In Vivo Level of Poly(ADP-ribose)

  • Masanao Miwa,
  • Chieri Ida,
  • Sachiko Yamashita,
  • Kenichi Kouyama,
  • Yasuhito Kuroda,
  • Takayuki Eguchi,
  • Narumi Ohta,
  • Teruaki Sato,
  • Masataka Tsuda and
  • Masakazu Tanaka

PolyADP-ribosylation is a post-translational modification that plays key roles in cellular physiological functions and DNA damage responses. PolyADP-ribosylation is finely and dynamically regulated by various enzymes and factors involved in the synth...

  • Article
  • Open Access
7 Citations
5,384 Views
19 Pages

ARTD10/PARP10 Induces ADP-Ribosylation of GAPDH and Recruits GAPDH into Cytosolic Membrane-Free Cell Bodies When Overexpressed in Mammalian Cells

  • Emilia Mayo,
  • Gaia Fabrizio,
  • Emanuele Salvatore Scarpa,
  • Annalisa Stilla,
  • Nadia Dani,
  • Fulvio Chiacchiera,
  • Henning Kleine,
  • Francesca Attanasio,
  • Bernhard Lüscher and
  • Maria Di Girolamo

Protein ADP-ribosylation is a reversible post-translational modification of cellular proteins that is catalysed by enzymes that transfer one (mono) or several (poly) units of ADP-ribose from β-NAD+ to a specific amino acid of the target protein....

  • Concept Paper
  • Open Access
5 Citations
7,163 Views
10 Pages

Cybernetics and the 4D Smart City: Smartness as Awareness

  • Emilia Rönkkö,
  • Aulikki Herneoja and
  • Essi Oikarinen

The complexity of urban challenges obliges us to seek smarter paths for urban development and increase our awareness of urban dynamics in a more holistic manner. Stemming from the discipline of architecture and urban planning, this concept paper outl...

  • Article
  • Open Access
4 Citations
7,988 Views
14 Pages

Value engineering (VE) and function analysis (FA) are technological tools for the functional enhancement and cost reduction of engineering projects. They also help to overcome mental inertia by acknowledging the voice of the customer in complicated s...

  • Viewpoint
  • Open Access
12 Citations
13,943 Views
6 Pages

Many researchers consider chronic fatigue syndrome (CFS) to be a synonym of Myalgic Encephalomyelitis (ME). However, the case criteria of ME and CFS define two distinct clinical entities. Although some patients will meet both case criteria, other pat...

  • Creative
  • Open Access
4 Citations
13,959 Views
9 Pages

This paper builds a link between isolated domains within the arts and sciences, specifically between music and psychiatry. An analogous model is presented that associates heavy metal music with bipolar disorder, a form of mental illness. Metal music...

  • Commentary
  • Open Access
38 Citations
7,571 Views
11 Pages

Soundscape research is attracting an ever-increasing worldwide interest from different disciplines and stakeholders. This brief commentary paper aims at offering some insights into the new directions this research (and practice) field will likely go,...

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Challenges - ISSN 2078-1547