Myalgic Encephalomyelitis, Chronic Fatigue Syndrome, and Systemic Exertion Intolerance Disease: Three Distinct Clinical Entities
Abstract
:1. Introduction
1.1. ME
1.2. CFS
1.3. SEID
1.4. ME, CFS, and SEID: Three Distinct Entities
1.5. Diagnosis
2. Conclusions
Conflicts of Interest
References
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ME (Ramsay) [1] | CFS (Fukuda) [2] | SEID (IOM/NAM) [3] | |
---|---|---|---|
Name and definition | 1957–1990 | 1994 (1988) | 2015 |
Onset | Illness commonly initiated by respiratory and/or gastrointestinal infection, but an insidious or more dramatic onset following neurological, cardiac, or endocrine disability occurs. | Unspecified | Unspecified |
Definition (distinctive symptoms) | Muscular symptoms, including prolonged postexertional muscle weakness (mandatory), myalgia, and muscle tenderness (often). Neurological symptoms, including cognitive impairment, day–night reversal, sensory dysfunction, and emotional lability. | Chronic fatigue (mandatory) and at least four of the following eight symptoms: Substantial impairment in short-term memory or concentration, a sore throat, tender lymph nodes, muscle pain, multijoint pain, headaches (of a new type, pattern, or severity), unrefreshing sleep, and postexertional “malaise”. | Chronic fatigue (not lifelong, not due to ongoing excessive exertion, and not alleviated by rest), postexertional “malaise”, unrefreshing sleep, and cognitive impairment and/or orthostatic intolerance. |
Other common symptoms | Cardiovascular impairment, and Autonomic dysfunction |
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Twisk, F.N.M. Myalgic Encephalomyelitis, Chronic Fatigue Syndrome, and Systemic Exertion Intolerance Disease: Three Distinct Clinical Entities. Challenges 2018, 9, 19. https://doi.org/10.3390/challe9010019
Twisk FNM. Myalgic Encephalomyelitis, Chronic Fatigue Syndrome, and Systemic Exertion Intolerance Disease: Three Distinct Clinical Entities. Challenges. 2018; 9(1):19. https://doi.org/10.3390/challe9010019
Chicago/Turabian StyleTwisk, Frank N.M. 2018. "Myalgic Encephalomyelitis, Chronic Fatigue Syndrome, and Systemic Exertion Intolerance Disease: Three Distinct Clinical Entities" Challenges 9, no. 1: 19. https://doi.org/10.3390/challe9010019