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Article

Impact of Pancreas Transplantation on the Patient Survival—An Analysis of the Japanese Pancreas Transplants Registry

1
Department of Transplantation and Regenerative Medicine, School of Medicine, Fujita Health University, Dengakugakubo 1-98, Kutsukakecho, Toyoake-shi, Aichi 470-1192, Japan
2
Gifu University Hospital, Innovative and Clinical Research Promotion Center, Gifu University, Gifu 501-1193, Japan
3
Department of Medical Statistics, Graduate School of Medicine, Osaka City University, Osaka 558-8585, Japan
4
The Japan Pancreas Transplant Registry, Japan Society for Pancreas & Islet Transplantation, Osaka 565-0871, Japan
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(7), 2134; https://doi.org/10.3390/jcm9072134
Received: 28 May 2020 / Revised: 27 June 2020 / Accepted: 29 June 2020 / Published: 6 July 2020
(This article belongs to the Special Issue Optimizing Outcomes of Pancreatic Surgery)
Background: The impact of pancreas transplantation, including kidney transplantation on patients’ life prognoses, is unclear in Japan. An analysis of the data of the Japan Pancreas Transplant Registry was performed to compare the patient survival between on the waiting list and after pancreas transplantation, and investigate the factors that affect the patient survival after pancreatic transplantation. Methods: The life prognoses of 361 patients who underwent pancreas transplantation from 2000 to December 2018 were examined. Results: The survival rates at 1, 5, and 10 years on the waiting list were 98.4%, 90.3%, and 78.1%, respectively, while those after transplantation were significantly improved (p = 0.029) at 100%, 97.5%, and 88.9%, respectively. Furthermore, the survival rates of patients waiting for simultaneous pancreas and kidney transplantation (SPK) at 1, 5, and 10 years were 98.2%, 89.4%, and 75.4%, respectively, while those after SPK were also significantly improved (p = 0.026) at 100%, 94.6%, and 88.8%. The multivariable analysis revealed that the duration of diabetes before surgery was the only independent risk factor (hazard ratio = 1.095, p = 0.012) that affected the patient survival after SPK. Conclusion: Pancreas transplantation was found to improve the life prognosis of patients with type 1 diabetes, especially those with end-stage renal failure waiting for SPK. View Full-Text
Keywords: pancreas transplantation; patient survival; type 1 diabetes; end-stage renal failure pancreas transplantation; patient survival; type 1 diabetes; end-stage renal failure
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MDPI and ACS Style

Ito, T.; Kenmochi, T.; Aida, N.; Matsushima, H.; Kurihara, K.; Ishihara, T.; Shintani, A.; Asaoka, T.; Ito, T. Impact of Pancreas Transplantation on the Patient Survival—An Analysis of the Japanese Pancreas Transplants Registry. J. Clin. Med. 2020, 9, 2134. https://doi.org/10.3390/jcm9072134

AMA Style

Ito T, Kenmochi T, Aida N, Matsushima H, Kurihara K, Ishihara T, Shintani A, Asaoka T, Ito T. Impact of Pancreas Transplantation on the Patient Survival—An Analysis of the Japanese Pancreas Transplants Registry. Journal of Clinical Medicine. 2020; 9(7):2134. https://doi.org/10.3390/jcm9072134

Chicago/Turabian Style

Ito, Taihei, Takashi Kenmochi, Naohiro Aida, Hajime Matsushima, Kei Kurihara, Takuma Ishihara, Ayumi Shintani, Tadafumi Asaoka, and Toshinori Ito. 2020. "Impact of Pancreas Transplantation on the Patient Survival—An Analysis of the Japanese Pancreas Transplants Registry" Journal of Clinical Medicine 9, no. 7: 2134. https://doi.org/10.3390/jcm9072134

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