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Article

Relationship between Soluble (Pro)Renin Receptor and Renin Activity in Patients with Severe Heart Failure

1
Department of Cardiology, Saitama Medical University International Medical Center, Saitama 350-1298, Japan
2
Department, Research Administration Center, Saitama Medical University, Saitama 350-1298, Japan
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(12), 4110; https://doi.org/10.3390/jcm9124110
Received: 8 November 2020 / Revised: 7 December 2020 / Accepted: 14 December 2020 / Published: 19 December 2020
(This article belongs to the Section Cardiology)
The (pro)renin receptor ((P)RR), which evokes renin activity with prorenin, is secreted extracellularly as soluble (P)RR (s(P)RR) and may participate in tissue renin-angiotensin system (RAS) activity in severe heart failure (HF) patients. The aim of this study was to determine whether s(P)RR is an adequate marker in severe HF patients treated with RAS inhibitors, beta-blockers, and tolvaptan. We enrolled 11 patients with severe HF between May 2013 and June 2014. First of all, furosemide of all patients was changed to tolvaptan with hydrochlorothiazide and then the treatment had been changed according to the patient’s condition. After 1, 3, 6, and 12 months, the variance of s(P)RR, plasma renin activity (PRA), plasma renin concentration (PRC), brain natriuretic peptide (BNP) and their association was investigated. Furosemide was restarted in five patients and two patients suffered cardiac death. PRA/PRC and s(P)RR were unchanged (PRA: 10.7 ± 13.9 to 12.8 ± 8.5 ng/mL/h; PRC: 347.1 ± 577.5 to 148.3 ± 123.8 pg/mL; s(P)RR: 28.2 ± 19.3 to 33.4 ± 22.4 ng/mL) and had no significant correlations (PRA and s(P)RR: p = 0.36; PRC and s(P)RR: p = 0.35). There was a significant positive correlation with a high correlation coefficient (CC) between PRA and PRC (p < 0.0001, CC = 0.76), and a negative correlation with weak CC between BNP and s(P)RR (p = 0.01, CC = −0.45). In conclusion, s(P)RR was always high and had no correlations with disease state and PRA/PRC in severe HF patients. View Full-Text
Keywords: renin-angiotensin system; (pro)renin receptor; heart failure; diuretics renin-angiotensin system; (pro)renin receptor; heart failure; diuretics
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MDPI and ACS Style

Ikeda, Y.; Tsutsui, K.; Yamada, Y.; Kato, R.; Muramatsu, T.; Senbonmatsu, T. Relationship between Soluble (Pro)Renin Receptor and Renin Activity in Patients with Severe Heart Failure. J. Clin. Med. 2020, 9, 4110. https://doi.org/10.3390/jcm9124110

AMA Style

Ikeda Y, Tsutsui K, Yamada Y, Kato R, Muramatsu T, Senbonmatsu T. Relationship between Soluble (Pro)Renin Receptor and Renin Activity in Patients with Severe Heart Failure. Journal of Clinical Medicine. 2020; 9(12):4110. https://doi.org/10.3390/jcm9124110

Chicago/Turabian Style

Ikeda, Yoshifumi, Kenta Tsutsui, Yoshihiro Yamada, Ritsushi Kato, Toshihiro Muramatsu, and Takaaki Senbonmatsu. 2020. "Relationship between Soluble (Pro)Renin Receptor and Renin Activity in Patients with Severe Heart Failure" Journal of Clinical Medicine 9, no. 12: 4110. https://doi.org/10.3390/jcm9124110

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