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Involvement of the Endocrine-Disrupting Chemical Bisphenol A (BPA) in Human Placentation
Review

Is There a Link between Bisphenol A (BPA), a Key Endocrine Disruptor, and the Risk for SARS-CoV-2 Infection and Severe COVID-19?

1
Biosciences, College of Health, Medicine and Life Sciences, Brunel University London, Uxbridge UB8 3PH, UK
2
Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals Coventry and Warwickshire NHS Trust, Coventry CV2 2DX, UK
3
Aston Medical Research Institute, Aston Medical School, Aston University, Birmingham B4 7ET, UK
4
Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
5
Department of Biochemistry and Immunology, University Hospitals Coventry and Warwickshire NHS Trust, Coventry CV2 2DX, UK
*
Author to whom correspondence should be addressed.
Ioannis Kyrou and Emmanouil Karteris are joint senior co-authors.
J. Clin. Med. 2020, 9(10), 3296; https://doi.org/10.3390/jcm9103296
Received: 27 August 2020 / Revised: 6 October 2020 / Accepted: 7 October 2020 / Published: 14 October 2020
Infection by the severe acute respiratory syndrome (SARS) coronavirus-2 (SARS-CoV-2) is the causative agent of a new disease (COVID-19). The risk of severe COVID-19 is increased by certain underlying comorbidities, including asthma, cancer, cardiovascular disease, hypertension, diabetes, and obesity. Notably, exposure to hormonally active chemicals called endocrine-disrupting chemicals (EDCs) can promote such cardio-metabolic diseases, endocrine-related cancers, and immune system dysregulation and thus, may also be linked to higher risk of severe COVID-19. Bisphenol A (BPA) is among the most common EDCs and exerts its effects via receptors which are widely distributed in human tissues, including nuclear oestrogen receptors (ERα and ERβ), membrane-bound oestrogen receptor (G protein-coupled receptor 30; GPR30), and human nuclear receptor oestrogen-related receptor gamma. As such, this paper focuses on the potential role of BPA in promoting comorbidities associated with severe COVID-19, as well as on potential BPA-induced effects on key SARS-CoV-2 infection mediators, such as angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2). Interestingly, GPR30 appears to exhibit greater co-localisation with TMPRSS2 in key tissues like lung and prostate, suggesting that BPA exposure may impact on the local expression of these SARS-CoV-2 infection mediators. Overall, the potential role of BPA on the risk and severity of COVID-19 merits further investigation. View Full-Text
Keywords: SARS-CoV-2; COVID-19; BPA; oestrogen receptors; ACE2; TMPRSS2; endocrine disruptors SARS-CoV-2; COVID-19; BPA; oestrogen receptors; ACE2; TMPRSS2; endocrine disruptors
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MDPI and ACS Style

Zahra, A.; Sisu, C.; Silva, E.; De Aguiar Greca, S.-C.; Randeva, H.S.; Chatha, K.; Kyrou, I.; Karteris, E. Is There a Link between Bisphenol A (BPA), a Key Endocrine Disruptor, and the Risk for SARS-CoV-2 Infection and Severe COVID-19? J. Clin. Med. 2020, 9, 3296. https://doi.org/10.3390/jcm9103296

AMA Style

Zahra A, Sisu C, Silva E, De Aguiar Greca S-C, Randeva HS, Chatha K, Kyrou I, Karteris E. Is There a Link between Bisphenol A (BPA), a Key Endocrine Disruptor, and the Risk for SARS-CoV-2 Infection and Severe COVID-19? Journal of Clinical Medicine. 2020; 9(10):3296. https://doi.org/10.3390/jcm9103296

Chicago/Turabian Style

Zahra, Aeman, Cristina Sisu, Elisabete Silva, Sophie-Christine De Aguiar Greca, Harpal S. Randeva, Kamaljit Chatha, Ioannis Kyrou, and Emmanouil Karteris. 2020. "Is There a Link between Bisphenol A (BPA), a Key Endocrine Disruptor, and the Risk for SARS-CoV-2 Infection and Severe COVID-19?" Journal of Clinical Medicine 9, no. 10: 3296. https://doi.org/10.3390/jcm9103296

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