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Non-Pharmacological Therapeutic Options for Liver Metastases in Advanced Neuroendocrine Tumors

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Gastroenterology and Digestive Oncology, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, 75014 Paris, France
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Department of Gastroenterology, Cochin Teaching Hospital, Université de Paris, 75014 Paris, France
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Department of Radiology, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, 75014 Paris, France
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Department of Nuclear Medicine, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, 75014 Paris, France
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Digestive Surgery Unit, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, 75014 Paris, France
*
Authors to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(11), 1907; https://doi.org/10.3390/jcm8111907
Received: 16 October 2019 / Revised: 29 October 2019 / Accepted: 5 November 2019 / Published: 7 November 2019
(This article belongs to the Section Oncology)
The incidence of liver metastasis in digestive neuroendocrine tumors is high. Their presence appears as an important prognostic factor in terms of quality of life and survival. These tumors may be symptomatic because of the tumor burden itself and/or the hormonal hyper-secretion induced by the tumor. Surgery is the treatment of choice for resectable tumors and metastasis. Nevertheless, surgery is only possible in a small number of cases. The management of non-resectable liver metastasis is a challenge. The literature is rich but consists predominantly in small retrospective series with a low level of proof. Thus, the choice of one technique over another could be difficult. Local ablative techniques (radiofrequency) or trans-catheter intra-arterial liver-directed treatments (hepatic artery embolization, chemo-embolization, and radio-embolization) are frequently considered for liver metastasis. In the present review, we focus on these different therapeutic approaches in advanced neuroendocrine tumors, results (clinical and radiological), and overall efficacy, and summarize recommendations to help physicians in their clinical practice. View Full-Text
Keywords: neuroendocrine tumors; liver metastasis; surgery; radiofrequency ablation; trans-arterial embolization; trans-arterial chemoembolization; trans-arterial radioembolization neuroendocrine tumors; liver metastasis; surgery; radiofrequency ablation; trans-arterial embolization; trans-arterial chemoembolization; trans-arterial radioembolization
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MDPI and ACS Style

Dermine, S.; Palmieri, L.-J.; Lavolé, J.; Barré, A.; Dohan, A.; Abou Ali, E.; Cottereau, A.-S.; Gaujoux, S.; Brezault, C.; Chaussade, S.; Coriat, R. Non-Pharmacological Therapeutic Options for Liver Metastases in Advanced Neuroendocrine Tumors. J. Clin. Med. 2019, 8, 1907.

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