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J. Clin. Med. 2018, 7(2), 14; https://doi.org/10.3390/jcm7020014

Prevalence of Vitamin D Deficiency Varies Widely by Season in Canadian Children and Adolescents with Sickle Cell Disease

1
Food, Nutrition, and Health, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
2
British Columbia Children’s Hospital Research Institute, Vancouver, BC V6H 3N1, Canada
3
Division of Hematology and Oncology, British Columbia Children’s Hospital, Vancouver, BC V6H 3N1, Canada
4
Division of Hematopathology, British Columbia Children’s Hospital, Vancouver, BC V6H 3N1, Canada
5
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
6
Department of Paediatrics, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
*
Author to whom correspondence should be addressed.
Received: 15 November 2017 / Revised: 10 January 2018 / Accepted: 15 January 2018 / Published: 30 January 2018
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Abstract

Sickle cell disease (SCD) is an inherited disorder caused by a variant (rs334) in the β-globin gene encoding hemoglobin. Individuals with SCD are thought to be at risk of vitamin D deficiency. Our aim was to assess serum 25-hydroxyvitamin D (25OHD) concentrations, estimate deficiency prevalence, and investigate factors associated with 25OHD concentrations in children and adolescents with SCD attending BC Children’s Hospital in Vancouver, Canada. We conducted a retrospective chart review of SCD patients (2–19 y) from 2012 to 2017. Data were available for n = 45 patients with n = 142 25OHD measurements assessed using a EUROIMMUN analyzer (EUROIMMUN Medizinische Labordiagnostika AG, Lübeck, Germany). Additional data were recorded, including age, sex, and season of blood collection. Linear regression was used to measure associations between 25OHD concentration and predictor variables. Overall, mean ± SD 25OHD concentration was 79 ± 36 nmol/L; prevalence of low 25OHD concentrations (<30, <40, and <75 nmol/L) was 5%, 17% and 50%, respectively. Mean 25OHD concentrations measured during Jul–Sep were higher (28 (95% confidence interval CI: 16–40) nmol/L higher, P < 0.001) compared to Jan–Mar. Vitamin D deficiency rates varied widely by season: Based on 25OHD <30 nmol/L, prevalence was 0% in Oct–Dec and 6% in Jan–Mar; based on <40 nmol/L, prevalence was 0% in Oct–Dec and 26% in Jan–Mar. View Full-Text
Keywords: sickle cell disease; vitamin D; 25-hydroxyvitamin D; pediatrics; nutrition; deficiency; hemoglobinopathy sickle cell disease; vitamin D; 25-hydroxyvitamin D; pediatrics; nutrition; deficiency; hemoglobinopathy
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Samson, K.L.I.; McCartney, H.; Vercauteren, S.M.; Wu, J.K.; Karakochuk, C.D. Prevalence of Vitamin D Deficiency Varies Widely by Season in Canadian Children and Adolescents with Sickle Cell Disease. J. Clin. Med. 2018, 7, 14.

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