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Electrospun Fibrous Scaffolds for Small-Diameter Blood Vessels: A Review

Biomechanics and Tissue Engineering Group, Swinburne University of Technology, Hawthorn, VIC 3122, Australia
Institute for Frontier Materials, Deakin University, Geelong, VIC 3216, Australia
Electrochemistry and Corrosion Laboratory, National Research Centre, Dokki, Cairo 12422, Egypt
College of Textile Engineering, Bahauddin Zakariya University, Multan 60800, Pakistan
Author to whom correspondence should be addressed.
Membranes 2018, 8(1), 15;
Received: 12 January 2018 / Revised: 31 January 2018 / Accepted: 28 February 2018 / Published: 6 March 2018
(This article belongs to the Special Issue Electrospun Nanofiber Membranes: Advances and Applications)
Small-diameter blood vessels (SDBVs) are still a challenging task to prepare due to the occurrence of thrombosis formation, intimal hyperplasia, and aneurysmal dilation. Electrospinning technique, as a promising tissue engineering approach, can fabricate polymer fibrous scaffolds that satisfy requirements on the construction of extracellular matrix (ECM) of native blood vessel and promote the adhesion, proliferation, and growth of cells. In this review, we summarize the polymers that are deployed for the fabrication of SDBVs and classify them into three categories, synthetic polymers, natural polymers, and hybrid polymers. Furthermore, the biomechanical properties and the biological activities of the electrospun SBVs including anti-thrombogenic ability and cell response are discussed. Polymer blends seem to be a strategic way to fabricate SDBVs because it combines both suitable biomechanical properties coming from synthetic polymers and favorable sites to cell attachment coming from natural polymers. View Full-Text
Keywords: SDBVs; thrombosis; electrospinning; fibrous scaffold; anti-thrombogenic agents SDBVs; thrombosis; electrospinning; fibrous scaffold; anti-thrombogenic agents
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Awad, N.K.; Niu, H.; Ali, U.; Morsi, Y.S.; Lin, T. Electrospun Fibrous Scaffolds for Small-Diameter Blood Vessels: A Review. Membranes 2018, 8, 15.

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