Abstract
The present study examined the safety of 86 veterinary antiparasitic drugs in mammals based on their mobility in the soil–water compartment, bioconcentration factor in fish, and blood–brain barrier permeability. An in silico analysis was performed based on biomembrane permeability descriptors, using novel multiple linear regression, boosted tree, and artificial neural network models. Additionally, intestinal absorption in humans was predicted quantitatively using pkCSM software and qualitatively using SwissADME. It was established that the majority of studied drugs are at least slightly mobile in soil, are unlikely to bioaccumulate in fish, and may be absorbed from the human gastro-intestinal tract; in addition, some of them have high potential to enter the mammalian brain.