Exploring the Willingness to Accept SARS-CoV-2 Vaccine in a University Population in Southern Italy, September to November 2020
Abstract
:1. Introduction
2. Materials and Methods
2.1. Participants
2.2. Procedures
2.3. Ethical Approval
2.4. Study Instrument
2.5. Data Analysis
3. Results
3.1. Socio-Demographic and Professional Characteristics
3.2. Attitudes
3.3. Sources of Information
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
- World Health Organization. WHO Director-General’s Opening Remarks at the Media Briefing on COVID- 19–11 March 2020. 2020. Available online: https://www.who.int/director-general/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19---11-march-2020march-2020 (accessed on 1 January 2021).
- World Health Organization. WHO Coronavirus Disease (COVID-19) Dashboard. Available online: https://covid19.who.int (accessed on 6 March 2021).
- Ministero della Salute Covid-19—Situazione in Italia. Available online: http://opendatadpc.maps.arcgis.com/apps/opsdashboard/index.html#/b0c68bce2cce478eaac82fe38d4138b1 (accessed on 6 March 2021).
- Di Giuseppe, G.; Pelullo, C.P.; Della Polla, G.; Montemurro, M.V.; Napolitano, F.; Pavia, M.; Angelillo, I.F. Surveying willingness towards SARS-CoV-2 vaccination of healthcare workers in Italy. Expert Rev. Vaccines 2020. under review. [Google Scholar]
- Hosmer, D.W.; Lemeshow, S. Applied Logistic Regression, 2nd ed.; Wiley: New York, NY, USA, 2000. [Google Scholar]
- Stata Corporation. Stata Reference Manual Release 15.1; Stata Corporation: College Station, TX, USA, 2017. [Google Scholar]
- Ministero della Salute. Legge 31 luglio 2017, n. 119. Conversione in Legge, con Modificazioni, del Decreto-Legge 7 Giugno 2017, n. 73, Recante Disposizioni Urgenti in Materia di Prevenzione Vaccinale. Available online: http://www.trovanorme.salute.gov.it/norme/dettaglioAtto?id=60201 (accessed on 1 January 2021).
- Kreps, S.; Prasad, S.; Brownstein, J.S.; Hswen, Y.; Garibaldi, B.T.; Zhang, B.; Kriner, D.L. Factors associated with US adults’ likelihood of accepting COVID-19 vaccination. JAMA Netw. Open 2020, 3, e2025594. [Google Scholar] [CrossRef]
- Neumann-Böhme, S.; Varghese, N.E.; Sabat, I.; Barros, P.P.; Brouwer, W.; Van Exel, J.; Schreyögg, J.; Stargardt, T. Once we have it, will we use it? A European survey on willingness to be vaccinated against COVID-19. Eur. J. Health Econ. 2020, 21, 977–982. [Google Scholar] [CrossRef]
- Reiter, P.L.; Pennell, M.L.; Katz, M.L. Acceptability of a COVID-19 vaccine among adults in the United States: How many people would get vaccinated? Vaccine 2020, 38, 6500–6507. [Google Scholar] [CrossRef]
- Yoda, T.; Katsuyama, H. Willingness to receive COVID-19 vaccination in Japan. Vaccines 2021, 9, 48. [Google Scholar] [CrossRef] [PubMed]
- Harapan, H.; Wagner, A.L.; Yufika, A.; Winardi, W.; Anwar, S.; Gan, A.K.; Setiawan, A.M.; Rajamoorthy, Y.; Sofyan, H.; Mudatsir, M. Acceptance of a COVID-19 vaccine in Southeast Asia: A cross-sectional study in Indonesia. Front. Public Health 2020, 8, 381. [Google Scholar] [CrossRef] [PubMed]
- Lin, Y.; Hu, Z.; Zhao, Q.; Alias, H.; Danaee, M.; Wong, L.P. Understanding COVID-19 vaccine demand and hesitancy: A nationwide online survey in China. PLOS Negl. Trop. Dis. 2020, 14, e0008961. [Google Scholar] [CrossRef] [PubMed]
- Wang, J.; Jing, R.; Lai, X.; Zhang, H.; Lyu, Y.; Knoll, M.D.; Fang, H. Acceptance of COVID-19 vaccination during the COVID-19 pandemic in China. Vaccines 2020, 8, 482. [Google Scholar] [CrossRef]
- Alley, S.J.; Stanton, R.; Browne, M.; To, Q.G.; Khalesi, S.; Williams, S.L.; Thwaite, T.L.; Fenning, A.S.; Vandelanotte, C. As the pandemic progresses, how does willingness to vaccinate against COVID-19 evolve? Int. J. Environ. Res. Public Health 2021, 18, 797. [Google Scholar] [CrossRef]
- Chen, M.; Li, Y.; Chen, J.; Wen, Z.; Feng, F.; Zou, H.; Fu, C.; Chen, L.; Shu, Y.; Sun, C. An online survey of the attitude and willingness of Chinese adults to receive COVID-19 vaccination. Hum. Vaccin. Immunother. 2021, 31, 1–10. [Google Scholar] [CrossRef]
- Wang, K.; Wong, E.L.; Ho, K.F.; Cheung, A.W.; Yau, P.S.; Dong, D.; Wong, S.Y.; Yeoh, E.K. Change of willingness to accept COVID-19 vaccine and reasons of vaccine hesitancy of working people at different waves of local epidemic in Hong Kong, China: Repeated cross-sectional surveys. Vaccines 2021, 9, 62. [Google Scholar] [CrossRef]
- Akarsu, B.; Canbay Özdemir, D.; Ayhan Baser, D.; Aksoy, H.; Fidancı, İ.; Cankurtaran, M. While studies on COVID-19 vaccine is ongoing, the public’s thoughts and attitudes to the future COVID-19 vaccine. Int. J. Clin. Pract. 2020, e13891. [Google Scholar] [CrossRef]
- Luz, P.M.; Johnson, R.E.; Brown, H.E. Workplace availability, risk group and perceived barriers predictive of 2016–17 influenza vaccine uptake in the United States: A cross-sectional study. Vaccine 2017, 35, 5890–5896. [Google Scholar] [CrossRef]
- Morrone, T.; Napolitano, F.; Albano, L.; Di Giuseppe, G. Meningococcal serogroup B vaccine: Knowledge and acceptability among parents in Italy. Hum. Vaccin Immunother. 2017, 13, 1921–1927. [Google Scholar] [CrossRef]
- Napolitano, F.; Napolitano, P.; Angelillo, I.F. Seasonal influenza vaccination in pregnant women: Knowledge, attitudes, and behaviors in Italy. BMC Infect. Dis. 2017, 17, 48. [Google Scholar] [CrossRef] [Green Version]
- Casalino, E.; Ghazali, A.; Bouzid, D.; Antoniol, S.; Pereira, L.; Kenway, P.; Choquet, C. Emergency Department study group on respiratory viruses. Patient’s behaviors and missed opportunities for vaccination against seasonal epidemic influenza and evaluation of their impact on patient’s influenza vaccine uptake. PLoS ONE 2018, 13, e0193029. [Google Scholar] [CrossRef] [Green Version]
- Bertoldo, G.; Pesce, A.; Pepe, A.; Pelullo, C.P.; Di Giuseppe, G. The Collaborative Working Group Seasonal influenza: Knowledge, attitude and vaccine uptake among adults with chronic conditions in Italy. PLoS ONE 2019, 14, e0215978. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Wong, L.P.; Alias, H.; Wong, P.-F.; Lee, H.Y.; Abubakar, S. The use of the health belief model to assess predictors of intent to receive the COVID-19 vaccine and willingness to pay. Hum. Vaccin. Immunother. 2020, 16, 2204–2214. [Google Scholar] [CrossRef]
- Al-Mohaithef, M.; Padhi, B.K. Determinants of COVID-19 vaccine acceptance in Saudi Arabia: A web-based national survey. J. Multidiscip. Healthc. 2020, 13, 1657–1663. [Google Scholar] [CrossRef] [PubMed]
- Sherman, S.M.; Smith, L.E.; Sim, J.; Amlôt, R.; Cutts, M.; Dasch, H.; Rubin, G.J.; Sevdalis, N. COVID-19 vaccination intention in the UK: Results from the COVID-19 vaccination acceptability study (CoVAccS), a nationally representative cross-sectional survey. Hum. Vaccin. Immunother. 2020, 26, 1–10. [Google Scholar] [CrossRef]
- Wang, K.; Wong, E.L.Y.; Ho, K.F.; Cheung, A.W.L.; Chan, E.Y.Y.; Yeoh, E.K.; Wong, S.Y.S. Intention of nurses to accept coronavirus disease 2019 vaccination and change of intention to accept seasonal influenza vaccination during the coronavirus disease 2019 pandemic: A cross-sectional survey. Vaccine 2020, 38, 7049–7056. [Google Scholar] [CrossRef] [PubMed]
- Galasso, V.; Pons, V.; Profeta, P.; Becher, M.; Brouard, S.; Foucault, M. Gender differences in COVID-19 attitudes and behavior: Panel evidence from eight countries. Proc. Natl. Acad. Sci. USA 2020, 117, 27285–27291. [Google Scholar] [CrossRef]
- He, S.; Chen, S.; Kong, L.; Liu, W. Analysis of risk perceptions and related factors concerning COVID-19 epidemic in Chongqing, China. J. Community Health 2021, 46, 278–285. [Google Scholar] [CrossRef]
- Kaufman, J.; Synnot, A.; Ryan, R.; Hill, S.; Horey, D.; Willis, N.; Lin, V.; Robinson, P. Face to face interventions for informing or educating parents about early childhood vaccination. Cochrane Database Syst. Rev. 2013, 5, CD010038. [Google Scholar] [CrossRef] [PubMed]
- Gagneur, A.; Lemaître, T.; Gosselin, V.; Farrands, A.; Carrier, N.; Petit, G.; Valiquette, L.; De Wals, P. A postpartum vaccination promotion intervention using motivational interviewing techniques improves short-term vaccine coverage: PromoVac study. BMC Public Health 2018, 18, 811. [Google Scholar] [CrossRef] [PubMed]
- Attwell, K.; Dube, E.; Gagneur, A.; Omer, S.B.; Suggs, L.S.; Thomson, A. Vaccine acceptance: Science, policy, and practice in a ‘post-fact’ world. Vaccine 2019, 37, 677–682. [Google Scholar] [CrossRef]
- Napolitano, F.; Ali Adou, A.; Vastola, A.; Angelillo, I.F. Rotavirus infection and vaccination: Knowledge, beliefs, and behaviors among parents in Italy. Int. J. Environ. Res. Public Health 2019, 16, 1807. [Google Scholar] [CrossRef] [Green Version]
Characteristics | N = 1518 | % |
---|---|---|
Age, years | 36 ± 14.2 (18–73) * | |
Gender | ||
Female | 923 | 60.8 |
Male | 595 | 39.2 |
Marital status | ||
Married/cohabitant | 504 | 33.3 |
Unmarried/widowed/separated/divorced | 1009 | 66.7 |
Education level | ||
High school degree or less | 804 | 53 |
College degree or higher | 714 | 47 |
Having at least a chronic medical condition | ||
No | 1224 | 80.6 |
Yes | 294 | 19.4 |
Professional role | ||
Students | 794 | 52.3 |
Administrative staff | 406 | 26.8 |
Faculty members | 214 | 14.1 |
Others (technicians, laboratory, security and cleaning staff) | 104 | 6.8 |
Contact with a confirmed COVID-19 case | ||
No | 1029 | 67.8 |
Yes | 489 | 32.2 |
Exposure to confirmed SARS-CoV-2 infection ^ | ||
Relatives | 156 | 31.9 |
Friends | 141 | 28.8 |
Co-workers | 101 | 20.7 |
Family members | 68 | 13.9 |
Household members | 23 | 4.7 |
Having at least one common symptom compatible with COVID-19 in the last ten months | ||
No | 1195 | 78.7 |
Yes | 323 | 21.3 |
Variable | Coeff. | t | p |
---|---|---|---|
Model 1. Perceived risk of developing COVID-19 (Sample size = 1504) | |||
F (6, 1497) = 26.1, p < 0.0001, R2 = 9.5%, adjusted R2 = 9.1% | |||
Younger | −0.02 | −3.69 | <0.001 |
Females | 0.8 | 7.27 | <0.001 |
Agree/strongly agree that COVID-19 is a severe disease | 1.23 | 8.34 | <0.001 |
Married/cohabitant | 0.25 | 1.65 | 0.099 |
Needing additional information regarding the vaccination against COVID-19 | 0.14 | 1.25 | 0.213 |
Having had in the previous ten months a common symptom compatible with COVID-19 | 0.15 | 1.21 | 0.226 |
OR | 95% CI | p | |
Model 2. No concern that the future COVID-19 vaccination might not be safe (Sample size = 1493) | |||
Log likelihood = −716.2, χ2 = 116.64(9 df), p < 0.0001 | |||
Males | 0.58 | 0.44–0.76 | <0.001 |
Professional role | |||
Faculty members | 1 * | ||
Administrative staff | 0.39 | 0.26–0.58 | <0.001 |
Others | 0.4 | 0.22–0.74 | 0.003 |
Did not need additional information regarding the vaccination against COVID-19 | 0.47 | 0.36–0.61 | <0.001 |
Not being married/cohabitant | 0.56 | 0.37–0.82 | 0.004 |
Perceived a lower risk of developing COVID-19 | 0.93 | 0.87–0.99 | 0.029 |
Having not received information regarding the vaccination against COVID-19 from mass media and the Internet | 0.75 | 0.53–1.06 | 0.106 |
Agree/strongly agree that COVID-19 is a severe disease | 1.32 | 0.89–1.96 | 0.162 |
Older | 1.01 | 1–1.02 | 0.164 |
Model 3. Willingness to receive a future vaccine against COVID-19 (Sample size = 1501) | |||
Log likelihood = −567.85, χ2 = 177 (8 df), p < 0.0001 | |||
Not concerned at all about the safety of the vaccination | 10.4 | 4.53–23.86 | <0.001 |
Agree/strongly agree that COVID-19 is a severe disease | 3.1 | 2.17–4.42 | <0.001 |
Professional role | |||
Faculty members | 1 * | ||
Administrative staff | 0.48 | 0.33–0.68 | <0.001 |
Others | 0.58 | 0.34–0.99 | 0.049 |
Males | 0.67 | 0.48–0.92 | 0.015 |
Not being married/cohabitant | 0.69 | 0.48–0.98 | 0.037 |
Perceived to be at a higher risk of developing COVID-19 | 1.05 | 0.98–1.13 | 0.147 |
High school degree or less | 0.84 | 0.62–1.15 | 0.288 |
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Di Giuseppe, G.; Pelullo, C.P.; Della Polla, G.; Pavia, M.; Angelillo, I.F. Exploring the Willingness to Accept SARS-CoV-2 Vaccine in a University Population in Southern Italy, September to November 2020. Vaccines 2021, 9, 275. https://doi.org/10.3390/vaccines9030275
Di Giuseppe G, Pelullo CP, Della Polla G, Pavia M, Angelillo IF. Exploring the Willingness to Accept SARS-CoV-2 Vaccine in a University Population in Southern Italy, September to November 2020. Vaccines. 2021; 9(3):275. https://doi.org/10.3390/vaccines9030275
Chicago/Turabian StyleDi Giuseppe, Gabriella, Concetta Paola Pelullo, Giorgia Della Polla, Maria Pavia, and Italo Francesco Angelillo. 2021. "Exploring the Willingness to Accept SARS-CoV-2 Vaccine in a University Population in Southern Italy, September to November 2020" Vaccines 9, no. 3: 275. https://doi.org/10.3390/vaccines9030275