Next Article in Journal / Special Issue
Harnessing the Power of T Cells: The Promising Hope for a Universal Influenza Vaccine
Previous Article in Journal
Immunogenicity in African Green Monkeys of M Protein Mutant Vesicular Stomatitis Virus Vectors and Contribution of Vector-Encoded Flagellin
Open AccessReview

Epidemiological Studies to Support the Development of Next Generation Influenza Vaccines

Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
*
Author to whom correspondence should be addressed.
Vaccines 2018, 6(2), 17; https://doi.org/10.3390/vaccines6020017
Received: 2 March 2018 / Revised: 21 March 2018 / Accepted: 21 March 2018 / Published: 26 March 2018
The National Institute of Allergy and Infectious Diseases recently published a strategic plan for the development of a universal influenza vaccine. This plan focuses on improving understanding of influenza infection, the development of influenza immunity, and rational design of new vaccines. Epidemiological studies such as prospective, longitudinal cohort studies are essential to the completion of these objectives. In this review, we discuss the contributions of epidemiological studies to our current knowledge of vaccines and correlates of immunity, and how they can contribute to the development and evaluation of the next generation of influenza vaccines. These studies have been critical in monitoring the effectiveness of current influenza vaccines, identifying issues such as low vaccine effectiveness, reduced effectiveness among those who receive repeated vaccination, and issues related to egg adaptation during the manufacturing process. Epidemiological studies have also identified population-level correlates of protection that can inform the design and development of next generation influenza vaccines. Going forward, there is an enduring need for epidemiological studies to continue advancing knowledge of correlates of protection and the development of immunity, to evaluate and monitor the effectiveness of next generation influenza vaccines, and to inform recommendations for their use. View Full-Text
Keywords: influenza; influenza vaccines; epidemiology; correlates of protection; hemagglutinin; neuraminidase influenza; influenza vaccines; epidemiology; correlates of protection; hemagglutinin; neuraminidase
MDPI and ACS Style

Petrie, J.G.; Gordon, A. Epidemiological Studies to Support the Development of Next Generation Influenza Vaccines. Vaccines 2018, 6, 17. https://doi.org/10.3390/vaccines6020017

AMA Style

Petrie JG, Gordon A. Epidemiological Studies to Support the Development of Next Generation Influenza Vaccines. Vaccines. 2018; 6(2):17. https://doi.org/10.3390/vaccines6020017

Chicago/Turabian Style

Petrie, Joshua G.; Gordon, Aubree. 2018. "Epidemiological Studies to Support the Development of Next Generation Influenza Vaccines" Vaccines 6, no. 2: 17. https://doi.org/10.3390/vaccines6020017

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop