Next Article in Journal
A Social Network Analysis of Tweets Related to Mandatory COVID-19 Vaccination in Poland
Previous Article in Journal
High Prevalence of Non-Vaccinated Oncogenic Human Papillomavirus Genotypes in High-Grade Squamous Intraepithelial Lesions of the Cervix: Thought-Provoking Results of a Detailed HPV Genotype Analysis
Article

COVID-19 Vaccines Confer Protection in Hospitalized Pregnant and Postpartum Women with Severe COVID-19: A Retrospective Cohort Study

1
Divisão de Clinica Obstetrica, Hospital das Clinicas HCFMUSP, Faculdade de Medicina da Universidade de São Paulo, 255 Dr Eneas Carvalho de Aguiar Avenue, 10th floor, São Paulo 05403-000, Brazil
2
Nuffield Department of Women’s and Reproductive Health, University of Oxford, Women’s Centre, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
3
Maternal Fetal Medicine Unit, Gold Coast University Hospital, School of Medicine, Griffith University, Gold Coast 4222, Australia
4
Gynecology and Obstetric Department, Ribeirão Preto Medical School, University of São Paulo, 3900 Bandeirantes Avenue, Ribeirão Preto, São Paulo 14049-900, Brazil
5
Departamento de Estatística, Universidade Federal do Espírito Santo, 514 Fernando Ferrari Avenue, Goiabeira, Vitória 29075-910, Brazil
6
Disciplina de Obstetrícia, Departamento de Obstetrícia e Ginecologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina da Universidade de São Paulo, São Paulo 05508-070, Brazil
*
Author to whom correspondence should be addressed.
Academic Editor: Ian H. Frazer
Vaccines 2022, 10(5), 749; https://doi.org/10.3390/vaccines10050749 (registering DOI)
Received: 6 April 2022 / Revised: 27 April 2022 / Accepted: 9 May 2022 / Published: 10 May 2022
The coronavirus disease 2019 (COVID-19) pandemic has had deleterious effects among the obstetric population. Pregnant and postpartum women constitute a high-risk group for severe COVID-19. Vaccination reduces the risk of infection, but it is not known whether women who become infected despite vaccination have a milder course of disease than those who had not been vaccinated. This retrospective cohort study evaluated whether vaccination reduces the severity of COVID-19 infection, as measured by severe maternal morbidity and mortality among hospitalized pregnant and postpartum individuals. A total of 2284 pregnant and postpartum women hospitalized with severe COVID-19 were included. Those who did and who did not receive COVID-19 vaccination were compared. The rates of intensive care unit admission, intubation, and mortality were significantly lower among subjects in the vaccinated group (p < 0.001, p < 0.001 and p < 0.001, respectively). The numbers of patients who needed to be vaccinated to avoid one case of intensive care unit admission, intubation, or death due to COVID-19 were 7, 7, and 9, respectively. The COVID-19 vaccine offers protective effects against intensive care unit admission, intubation, and death in hospitalized pregnant and postpartum women with severe SARS-CoV-2-induced SARS. View Full-Text
Keywords: COVID-19 vaccines; pregnancy; maternal mortality; intubation; intensive care unit; severe acute respiratory syndrome COVID-19 vaccines; pregnancy; maternal mortality; intubation; intensive care unit; severe acute respiratory syndrome
Show Figures

Figure 1

MDPI and ACS Style

de Freitas Paganoti, C.; Alkmin da Costa, R.; Papageorghiou, A.T.; da Silva Costa, F.; Quintana, S.M.; Graziela de Godoi, L.; Adriana Jiménez Monroy, N.; Sacramento Rodrigues, A.; Pulcineli Vieira Francisco, R. COVID-19 Vaccines Confer Protection in Hospitalized Pregnant and Postpartum Women with Severe COVID-19: A Retrospective Cohort Study. Vaccines 2022, 10, 749. https://doi.org/10.3390/vaccines10050749

AMA Style

de Freitas Paganoti C, Alkmin da Costa R, Papageorghiou AT, da Silva Costa F, Quintana SM, Graziela de Godoi L, Adriana Jiménez Monroy N, Sacramento Rodrigues A, Pulcineli Vieira Francisco R. COVID-19 Vaccines Confer Protection in Hospitalized Pregnant and Postpartum Women with Severe COVID-19: A Retrospective Cohort Study. Vaccines. 2022; 10(5):749. https://doi.org/10.3390/vaccines10050749

Chicago/Turabian Style

de Freitas Paganoti, Cristiane, Rafaela Alkmin da Costa, Aris T. Papageorghiou, Fabrício da Silva Costa, Silvana M. Quintana, Luciana Graziela de Godoi, Nátaly Adriana Jiménez Monroy, Agatha Sacramento Rodrigues, and Rossana Pulcineli Vieira Francisco. 2022. "COVID-19 Vaccines Confer Protection in Hospitalized Pregnant and Postpartum Women with Severe COVID-19: A Retrospective Cohort Study" Vaccines 10, no. 5: 749. https://doi.org/10.3390/vaccines10050749

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop