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Open AccessArticle

Human DNA Telomeres in Presence of Oxidative Lesions: The Crucial Role of Electrostatic Interactions on the Stability of Guanine Quadruplexes

1
Université de Lorraine, CNRS, LPCT UMR 7019, F54000 Nancy, France
2
Department of Biological, Chenical and Pharmaceutical Sciences and Technologies, Università di Palermo, Viale delle Scienze, 90128 Palermo, Italy
*
Authors to whom correspondence should be addressed.
Antioxidants 2019, 8(9), 337; https://doi.org/10.3390/antiox8090337
Received: 15 July 2019 / Revised: 14 August 2019 / Accepted: 20 August 2019 / Published: 22 August 2019
(This article belongs to the Special Issue Oxidative Stress, DNA Damage and Biological Clinical Effects)
By using all atom molecular dynamics simulations, we studied the behavior of human DNA telomere sequences in guanine quadruplex (G4) conformation and in the presence of oxidative lesions, namely abasic sites. In particular, we evidenced that while removing one guanine base induces a significant alteration and destabilization of the involved leaflet, human telomere oligomers tend, in most cases, to maintain at least a partial quadruplex structure, eventually by replacing the empty site with undamaged guanines of different leaflets. This study shows that (i) the disruption of the quadruplex leaflets induces the release of at least one of the potassium cations embedded in the quadruplex channel and that (ii) the electrostatic interactions of the DNA sequence with the aforementioned cations are fundamental to the maintenance of the global quadruplex structure. View Full-Text
Keywords: human DNA telomeres; oxidative lesions; guanine quadruplexes; all atom molecular dynamics human DNA telomeres; oxidative lesions; guanine quadruplexes; all atom molecular dynamics
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Hognon, C.; Gebus, A.; Barone, G.; Monari, A. Human DNA Telomeres in Presence of Oxidative Lesions: The Crucial Role of Electrostatic Interactions on the Stability of Guanine Quadruplexes. Antioxidants 2019, 8, 337.

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