Next Article in Journal
Propolis Extracts Inhibit UV-Induced Photodamage in Human Experimental In Vitro Skin Models
Previous Article in Journal
Carotenoid Production by Dunaliella salina under Red Light
Previous Article in Special Issue
Mitochondria-Targeted Antioxidants for Treatment of Hearing Loss: A Systematic Review
Article Menu

Export Article

Open AccessPerspective

Mitochondria-Targeted Antioxidants as Potential Therapy for the Treatment of Traumatic Brain Injury

1
Research Center of Neurology,w 125367, Russia
2
Biological Faculty, N.A. Belozersky Institute of Physico-Chemical Biology, M.V. Lomonosovw State University,w 119991, Russia
*
Author to whom correspondence should be addressed.
Antioxidants 2019, 8(5), 124; https://doi.org/10.3390/antiox8050124
Received: 3 March 2019 / Revised: 30 April 2019 / Accepted: 6 May 2019 / Published: 8 May 2019
(This article belongs to the Special Issue Mitochondria-Targeted Antioxidants)
  |  
PDF [802 KB, uploaded 8 May 2019]
  |  

Abstract

The aim of this article is to review the publications describing the use of mitochondria-targeted antioxidant therapy after traumatic brain injury (TBI). Recent works demonstrated that mitochondria-targeted antioxidants are very effective in reducing the negative effects associated with the development of secondary damage caused by TBI. Using various animal models of TBI, mitochondria-targeted antioxidants were shown to prevent cardiolipin oxidation in the brain and neuronal death, as well as to markedly reduce behavioral deficits and cortical lesion volume, brain water content, and DNA damage. In the future, not only a more detailed study of the mechanisms of action of various types of such antioxidants needs to be conducted, but also their therapeutic values and toxicological properties are to be determined. Moreover, the optimal therapeutic effect needs to be achieved in the shortest time possible from the onset of damage to the nervous tissue, since secondary brain damage in humans can develop for a long time, days and even months, depending on the severity of the damage. View Full-Text
Keywords: mitochondria-targeted antioxidant; traumatic brain injury; mitochondria mitochondria-targeted antioxidant; traumatic brain injury; mitochondria
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Stelmashook, E.V.; Isaev, N.K.; Genrikhs, E.E.; Novikova, S.V. Mitochondria-Targeted Antioxidants as Potential Therapy for the Treatment of Traumatic Brain Injury. Antioxidants 2019, 8, 124.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Antioxidants EISSN 2076-3921 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top