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Open AccessArticle

Penta-1,2,3,4,6-O-Galloyl-β-d-Glucose Inhibits UVB-Induced Photoaging by Targeting PAK1 and JNK1

by Ji-An Kim 1,†, Jae-Eun Lee 1,†, Ji Hye Kim 1,2, Hyo-Jeong Lee 3 and Nam Joo Kang 1,*
1
School of Food Science and Biotechnology, Kyungpook National University, Daegu 41566, Korea
2
Korean Medicine (KM)-Application Center, Korea Institute of Oriental Medicine (KIOM), Daegu 41062, Korea
3
College of Korean Medicine, Cancer Preventive Material Research Center, Kyunghee University, Seoul 02447, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Antioxidants 2019, 8(11), 561; https://doi.org/10.3390/antiox8110561
Received: 17 October 2019 / Revised: 6 November 2019 / Accepted: 13 November 2019 / Published: 15 November 2019
(This article belongs to the Special Issue Antioxidants in Cosmetics)
Penta-O-galloyl-β-d-glucose (PGG) is a gallotannin polyphenolic compound that occurs naturally in fermented Rhus verniciflua. The present study aimed to examine the effect of PGG on UVB-induced skin aging and its molecular mechanisms in HaCaT human keratinocytes and SKH-1 hairless mice models. PGG suppressed UVB-induced matrix metalloproteinase-1 (MMP-1) expression in HaCaT cells by inhibiting phosphorylation of RAF/MEK/ERK, MKK3/6/p38, and c-Jun. UVB-induced ERK and p38 signaling pathways that induce the MMP-1 expression were mediated by PAK1 in HaCaT cells. PGG suppressed PAK1 and JNK1 kinase activities, and directly bound both PAK1 in an ATP-competitive manner and JNK1 in an ATP-noncompetitive manner. Consistently, PGG decreased UVB-induced wrinkle formation, epidermal thickness, type 1 collagen and MMP-13 expression in mouse skin. Overall, these results indicate that PGG exhibits anti-photoaging effects in vitro and in vivo by the suppression of PAK1 and JNK1 kinase activities, and may be useful for the prevention of skin aging. View Full-Text
Keywords: penta-1,2,3,4,6-O-galloyl-β-d-glucose; JNK1; PAK1; photoaging; ultraviolet B penta-1,2,3,4,6-O-galloyl-β-d-glucose; JNK1; PAK1; photoaging; ultraviolet B
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Kim, J.-A.; Lee, J.-E.; Kim, J.H.; Lee, H.-J.; Kang, N.J. Penta-1,2,3,4,6-O-Galloyl-β-d-Glucose Inhibits UVB-Induced Photoaging by Targeting PAK1 and JNK1. Antioxidants 2019, 8, 561.

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