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Open AccessArticle

Combination of PDT and NOPDT with a Tailored BODIPY Derivative

Department of Drug Science and Technology, University of Torino, 10125 Torino, Italy
Department of Oncology, University of Torino, 10126 Torino, Italy
Department of Chemistry, University of Torino, 10125 Torino, Italy
Department of Drug Sciences, University of Catania, 95125 Catania, Italy
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Antioxidants 2019, 8(11), 531;
Received: 9 October 2019 / Revised: 30 October 2019 / Accepted: 5 November 2019 / Published: 7 November 2019
(This article belongs to the Special Issue Free Radical Research in Cancer)
The engineering of photosensitizers (PS) for photodynamic therapy (PDT) with nitric oxide (NO) photodonors (NOPD) is broadening the horizons for new and yet to be fully explored unconventional anticancer treatment modalities that are entirely controlled by light stimuli. In this work, we report a tailored boron-dipyrromethene (BODIPY) derivative that acts as a PS and a NOPD simultaneously upon single photon excitation with highly biocompatible green light. The photogeneration of the two key species for PDT and NOPDT, singlet oxygen (1O2) and NO, has been demonstrated by their direct detection, while the formation of NO is shown not to be dependent on the presence of oxygen. Biological studies carried out using A375 and SKMEL28 cancer cell lines, with the aid of suitable model compounds that are based on the same BODIPY light harvesting core, unambiguously reveal the combined action of 1O2 and NO in inducing amplified cancer cell mortality exclusively under irradiation with visible green light. View Full-Text
Keywords: photodynamic therapy; singlet oxygen; nitric oxide; light; combination therapy photodynamic therapy; singlet oxygen; nitric oxide; light; combination therapy
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MDPI and ACS Style

Lazzarato, L.; Gazzano, E.; Blangetti, M.; Fraix, A.; Sodano, F.; Picone, G.M.; Fruttero, R.; Gasco, A.; Riganti, C.; Sortino, S. Combination of PDT and NOPDT with a Tailored BODIPY Derivative. Antioxidants 2019, 8, 531.

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