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Open AccessArticle

Antiplatelet Activity of Natural Bioactive Extracts from Mango (Mangifera Indica L.) and its By-Products

Area of Food Technology, Regional Institute for Applied Scientific Research (IRICA), University of Castilla-La Mancha. Avda. Camilo José Cela, 10, 13071 Ciudad Real, Spain
Department of Analytical Chemistry, Faculty of Sciences, University of Granada, C/Fuentenueva s/n, 18071 Granada, Spain
Research and Development of Functional Food Centre (CIDAF), PTS Granada, Avda. Del Conocimiento 37, Bioregión Building, 18016 Granada, Spain
Thrombosis Research Center, Department of Clinical Biochemistry and Immunohaematology, Faculty of Health Sciences, Interdisciplinary Center on Aging (CIE), University of Talca, 3460000 Talca, Chile
Authors to whom correspondence should be addressed.
Both authors are joint senior researchers on this work.
Antioxidants 2019, 8(11), 517;
Received: 2 October 2019 / Revised: 21 October 2019 / Accepted: 26 October 2019 / Published: 29 October 2019
(This article belongs to the Special Issue Polyphenolic Antioxidants from Agri-Food Waste Biomass)
The potential antiplatelet aggregation effects of mango pulp and its by-products (peel, husk seed, and seed) due to the presence of bioactive compounds were explored. Among them, mango seed exhibited a 72% percentage inhibition of platelet aggregation induced by adenosine 5’-diphosphate (ADP) agonist with a demonstrated dose-dependent effect. This biological feature could be caused by the chemical differences in phenolic composition. Mango seed was especially rich in monogalloyl compounds, tetra- and penta-galloylglucose, ellagic acid, mangiferin, and benzophenones such as maclurin derivatives and iriflophenone glucoside. Mangiferin showed an inhibitory effect of 31%, suggesting its key role as one of the main contributors to the antiplatelet activity of mango seed. Therefore, mango seed could be postulated as a natural source of bioactive compounds with antiplatelet properties to design functional foods or complementary therapeutic treatments. View Full-Text
Keywords: Mango; by-products; antiplatelet activity; bioactive compounds; HPLC-DAD-q-TOF-MS Mango; by-products; antiplatelet activity; bioactive compounds; HPLC-DAD-q-TOF-MS
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MDPI and ACS Style

Alañón, M.E.; Palomo, I.; Rodríguez, L.; Fuentes, E.; Arráez-Román, D.; Segura-Carretero, A. Antiplatelet Activity of Natural Bioactive Extracts from Mango (Mangifera Indica L.) and its By-Products. Antioxidants 2019, 8, 517.

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