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Open AccessArticle

Antiplatelet Activity of Natural Bioactive Extracts from Mango (Mangifera Indica L.) and its By-Products

1
Area of Food Technology, Regional Institute for Applied Scientific Research (IRICA), University of Castilla-La Mancha. Avda. Camilo José Cela, 10, 13071 Ciudad Real, Spain
2
Department of Analytical Chemistry, Faculty of Sciences, University of Granada, C/Fuentenueva s/n, 18071 Granada, Spain
3
Research and Development of Functional Food Centre (CIDAF), PTS Granada, Avda. Del Conocimiento 37, Bioregión Building, 18016 Granada, Spain
4
Thrombosis Research Center, Department of Clinical Biochemistry and Immunohaematology, Faculty of Health Sciences, Interdisciplinary Center on Aging (CIE), University of Talca, 3460000 Talca, Chile
*
Authors to whom correspondence should be addressed.
Both authors are joint senior researchers on this work.
Antioxidants 2019, 8(11), 517; https://doi.org/10.3390/antiox8110517
Received: 2 October 2019 / Revised: 21 October 2019 / Accepted: 26 October 2019 / Published: 29 October 2019
(This article belongs to the Special Issue Polyphenolic Antioxidants from Agri-Food Waste Biomass)
The potential antiplatelet aggregation effects of mango pulp and its by-products (peel, husk seed, and seed) due to the presence of bioactive compounds were explored. Among them, mango seed exhibited a 72% percentage inhibition of platelet aggregation induced by adenosine 5’-diphosphate (ADP) agonist with a demonstrated dose-dependent effect. This biological feature could be caused by the chemical differences in phenolic composition. Mango seed was especially rich in monogalloyl compounds, tetra- and penta-galloylglucose, ellagic acid, mangiferin, and benzophenones such as maclurin derivatives and iriflophenone glucoside. Mangiferin showed an inhibitory effect of 31%, suggesting its key role as one of the main contributors to the antiplatelet activity of mango seed. Therefore, mango seed could be postulated as a natural source of bioactive compounds with antiplatelet properties to design functional foods or complementary therapeutic treatments. View Full-Text
Keywords: Mango; by-products; antiplatelet activity; bioactive compounds; HPLC-DAD-q-TOF-MS Mango; by-products; antiplatelet activity; bioactive compounds; HPLC-DAD-q-TOF-MS
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MDPI and ACS Style

Alañón, M.E.; Palomo, I.; Rodríguez, L.; Fuentes, E.; Arráez-Román, D.; Segura-Carretero, A. Antiplatelet Activity of Natural Bioactive Extracts from Mango (Mangifera Indica L.) and its By-Products. Antioxidants 2019, 8, 517.

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