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Antioxidants 2018, 7(12), 185; https://doi.org/10.3390/antiox7120185

Effect of Agraz (Vaccinium meridionale Swartz) on High-Density Lipoprotein Function and Inflammation in Women with Metabolic Syndrome

1
Food and therapeutic alternatives area, Ophidism Program, School of Microbiology, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellín 050010, Colombia
2
Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
3
Research Group of Physiology and Biochemistry (PHYSIS), School of Nutrition and Dietetics, Universidad de Antioquia UdeA. Calle 70 No. 52-21, Medellín 050010, Colombia
*
Author to whom correspondence should be addressed.
Received: 24 October 2018 / Revised: 3 December 2018 / Accepted: 4 December 2018 / Published: 8 December 2018
(This article belongs to the Special Issue Antioxidants in Oxidative Stress Diseases)
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Abstract

Metabolic syndrome (MetS) is associated with low-grade inflammation and high-density lipoprotein (HDL) dysfunction. Polyphenol-rich foods may improve these alterations. Agraz is a fruit rich in polyphenols (mainly anthocyanins); however, there is limited information about its effects on human health. We evaluated the effects of agraz consumption as compared to placebo on HDL function and inflammation in women with MetS. Forty volunteers (25–60 years) were included in this double-blind crossover study. Women consumed agraz or placebo over 4 weeks; separated by a 4-week washout period. HDL function (apoliprotein-A1; paraoxonase 1 (PON1) activity; cholesterol efflux capacity), oxidative stress (myeloperoxidase (MPO), advanced oxidation protein products) and inflammatory markers (serum cytokines/chemokines and peripheral blood mononuclear cell nuclear factor-kB) were measured after each period. Compared to placebo, agraz consumption did not significantly change any of the biomarkers measured. Interestingly, only after agraz period there were significant positive correlations between PON1 activities and cholesterol efflux. Additionally, there were significant inverse correlations between changes in inflammatory markers and HDL function markers and positive correlations with oxidative markers. Although polyphenol-rich foods have been shown to be beneficial for certain conditions; polyphenol-rich agraz fruit consumption did not impact inflammation and HDL function in the current study of women with MetS. View Full-Text
Keywords: Andean berry; cardiovascular risk factors; HDL dysfunction; inflammation; oxidative stress Andean berry; cardiovascular risk factors; HDL dysfunction; inflammation; oxidative stress
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Marín-Echeverri, C.; Blesso, C.N.; Fernández, M.L.; Galvis-Pérez, Y.; Ciro-Gómez, G.; Núñez-Rangel, V.; Aristizábal, J.C.; Barona-Acevedo, J. Effect of Agraz (Vaccinium meridionale Swartz) on High-Density Lipoprotein Function and Inflammation in Women with Metabolic Syndrome. Antioxidants 2018, 7, 185.

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